Allelic dropout in the endoglin (ENG) gene caused by common duplication beyond the primer binding site

Allelic dropout (ADO) is a common limitation of all PCR-based molecular diagnostic methods, leading to false-negative or false-positive results, depending on the allele that was dropped. We report a case of multiple locus-specific allele dropouts mediated by a common duplication beyond the primer-bi...

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Bibliographic Details
Main Authors: Anna G. Shestak, Victoria A. Rumyantseva, Elena V. Zaklyazminskaya
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Genetics
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Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1571437/full
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