Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid
Daniel Neider, Leif H Lindström, Robert Bodén Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden Background: The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA)...
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Dove Medical Press
2016-07-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/risk-factors-for-suicide-among-patients-with-schizophrenia-a-cohort-st-peer-reviewed-fulltext-article-NDT |
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| author | Neider D Lindström L Boden R |
| author_facet | Neider D Lindström L Boden R |
| author_sort | Neider D |
| collection | DOAJ |
| description | Daniel Neider, Leif H Lindström, Robert Bodén Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden Background: The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF), bullying, and later suicide among patients with schizophrenia. Methods: Ninety-nine patients with schizophrenia were included. Correlations of clinical factors, 5-HIAA and HVA, and later suicide were investigated. Results: Twelve patients committed suicide (12%) during a 28-year follow-up period. Later suicide was correlated to bullying in childhood (P=0.02) and a lower quotient of HVA/5-HIAA in CSF (P<0.05). Conclusion: Suicide in schizophrenia is related to childhood exposedness and CSF neurotransmitter levels. Keywords: psychosis, risk factors, bullying, HVA, 5-HIAA, CSF |
| format | Article |
| id | doaj-art-e1b589026c9c41a7b9b95e34d497d030 |
| institution | Matheson Library |
| issn | 1178-2021 |
| language | English |
| publishDate | 2016-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj-art-e1b589026c9c41a7b9b95e34d497d0302025-06-26T01:58:36ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212016-07-01Volume 12Issue 11711171427850Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acidNeider D0Lindström LBoden R1PsychiatryNeuroscience, PsychiatryDaniel Neider, Leif H Lindström, Robert Bodén Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden Background: The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF), bullying, and later suicide among patients with schizophrenia. Methods: Ninety-nine patients with schizophrenia were included. Correlations of clinical factors, 5-HIAA and HVA, and later suicide were investigated. Results: Twelve patients committed suicide (12%) during a 28-year follow-up period. Later suicide was correlated to bullying in childhood (P=0.02) and a lower quotient of HVA/5-HIAA in CSF (P<0.05). Conclusion: Suicide in schizophrenia is related to childhood exposedness and CSF neurotransmitter levels. Keywords: psychosis, risk factors, bullying, HVA, 5-HIAA, CSFhttps://www.dovepress.com/risk-factors-for-suicide-among-patients-with-schizophrenia-a-cohort-st-peer-reviewed-fulltext-article-NDTKey words: suicideschizophreniabullyingHVA5-HIAACSF |
| spellingShingle | Neider D Lindström L Boden R Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid Neuropsychiatric Disease and Treatment Key words: suicide schizophrenia bullying HVA 5-HIAA CSF |
| title | Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid |
| title_full | Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid |
| title_fullStr | Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid |
| title_full_unstemmed | Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid |
| title_short | Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid |
| title_sort | risk factors for suicide among patients with schizophrenia a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5 hydroxyindoleacetic acid |
| topic | Key words: suicide schizophrenia bullying HVA 5-HIAA CSF |
| url | https://www.dovepress.com/risk-factors-for-suicide-among-patients-with-schizophrenia-a-cohort-st-peer-reviewed-fulltext-article-NDT |
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