Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF
On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC “Publisher OKI”
2016-03-01
|
| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/168 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839591645006266368 |
|---|---|
| author | T. A. Antipova I. O. Logvinov S. V. Nikolaev S. V. Kruglov A. V. Tarasiuk P. I. Antipov T. A. Gudasheva S. B. Seredenin |
| author_facet | T. A. Antipova I. O. Logvinov S. V. Nikolaev S. V. Kruglov A. V. Tarasiuk P. I. Antipov T. A. Gudasheva S. B. Seredenin |
| author_sort | T. A. Antipova |
| collection | DOAJ |
| description | On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10-6M)) evoke activation of two main signal cascades - PI3/Akt and MAP/Erk, while mimetic the 4th loop of NGF (GK-2 (10-8M)) only one - a PI3/Akt-way. |
| format | Article |
| id | doaj-art-e196399e3ccb4e7e86fdadb54fb902b5 |
| institution | Matheson Library |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2016-03-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-e196399e3ccb4e7e86fdadb54fb902b52025-08-03T13:00:46ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302016-03-01021417167Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGFT. A. Antipova0I. O. Logvinov1S. V. Nikolaev2S. V. Kruglov3A. V. Tarasiuk4P. I. Antipov5T. A. Gudasheva6S. B. Seredenin7FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10-6M)) evoke activation of two main signal cascades - PI3/Akt and MAP/Erk, while mimetic the 4th loop of NGF (GK-2 (10-8M)) only one - a PI3/Akt-way.https://www.pharmacokinetica.ru/jour/article/view/168ngftrk-aвнутриклеточный сигналингдимерные дипептидные миметикиngftrk-aintracellular signalingdimeric dipeptide mimetiks |
| spellingShingle | T. A. Antipova I. O. Logvinov S. V. Nikolaev S. V. Kruglov A. V. Tarasiuk P. I. Antipov T. A. Gudasheva S. B. Seredenin Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF Фармакокинетика и Фармакодинамика ngf trk-a внутриклеточный сигналинг димерные дипептидные миметики ngf trk-a intracellular signaling dimeric dipeptide mimetiks |
| title | Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF |
| title_full | Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF |
| title_fullStr | Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF |
| title_full_unstemmed | Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF |
| title_short | Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF |
| title_sort | comparative analysis activation of post receptor signal ways by dimeric dipeptide mimetiks of different loops of ngf |
| topic | ngf trk-a внутриклеточный сигналинг димерные дипептидные миметики ngf trk-a intracellular signaling dimeric dipeptide mimetiks |
| url | https://www.pharmacokinetica.ru/jour/article/view/168 |
| work_keys_str_mv | AT taantipova comparativeanalysisactivationofpostreceptorsignalwaysbydimericdipeptidemimetiksofdifferentloopsofngf AT iologvinov comparativeanalysisactivationofpostreceptorsignalwaysbydimericdipeptidemimetiksofdifferentloopsofngf AT svnikolaev comparativeanalysisactivationofpostreceptorsignalwaysbydimericdipeptidemimetiksofdifferentloopsofngf AT svkruglov comparativeanalysisactivationofpostreceptorsignalwaysbydimericdipeptidemimetiksofdifferentloopsofngf AT avtarasiuk comparativeanalysisactivationofpostreceptorsignalwaysbydimericdipeptidemimetiksofdifferentloopsofngf AT piantipov comparativeanalysisactivationofpostreceptorsignalwaysbydimericdipeptidemimetiksofdifferentloopsofngf AT tagudasheva comparativeanalysisactivationofpostreceptorsignalwaysbydimericdipeptidemimetiksofdifferentloopsofngf AT sbseredenin comparativeanalysisactivationofpostreceptorsignalwaysbydimericdipeptidemimetiksofdifferentloopsofngf |