Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF

Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF

On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10...

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Bibliographic Details
Main Authors: T. A. Antipova, I. O. Logvinov, S. V. Nikolaev, S. V. Kruglov, A. V. Tarasiuk, P. I. Antipov, T. A. Gudasheva, S. B. Seredenin
Format: Article
Language:Russian
Published: LLC “Publisher OKI” 2016-03-01
Series:Фармакокинетика и Фармакодинамика
Subjects:
ngf
trk-a
внутриклеточный сигналинг
димерные дипептидные миметики
intracellular signaling
dimeric dipeptide mimetiks
Online Access:https://www.pharmacokinetica.ru/jour/article/view/168
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Summary:On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10-6M)) evoke activation of two main signal cascades - PI3/Akt and MAP/Erk, while mimetic the 4th loop of NGF (GK-2 (10-8M)) only one - a PI3/Akt-way.
ISSN:2587-7836
2686-8830

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