Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women
Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel–Palade bodies, which can affect activity of ADAMTS-13 metalloproteinase (a disintegrin and metallo...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2023-03-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/1560 |
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| author | N. R. Gashimova K. N. Grigoreva V. O. Bitsadze L. L. Pankratyeva J. Kh. Khizroeva M. V. Tretyakova Ya. M. Shammut E. Iu. Iupatov V. I. Tsibizova J.-K. Gris D. V. Blinov A. D. Makatsariya |
| author_facet | N. R. Gashimova K. N. Grigoreva V. O. Bitsadze L. L. Pankratyeva J. Kh. Khizroeva M. V. Tretyakova Ya. M. Shammut E. Iu. Iupatov V. I. Tsibizova J.-K. Gris D. V. Blinov A. D. Makatsariya |
| author_sort | N. R. Gashimova |
| collection | DOAJ |
| description | Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel–Palade bodies, which can affect activity of ADAMTS-13 metalloproteinase (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) and the ADAMTS-13/vWF axis previously shown by us to be altered in non-pregnant women with severe COVID-19. Aim: to study a clinical role of hemostasis activation particularly ADAMTS-13/vWF axis in pregnant women after COVID-19. Materials and Methods. A prospective case–control study was conducted with pregnant women (n = 135) divided into 3 groups: group 1 included 45 women with prior COVID-19 during pregnancy, group 2 – 45 women in the acute phase of the infection during pregnancy, group 3 – 45 healthy pregnant women. The level of vWF and ADAMTS-13 was assessed in all patients. Results. The concentration of vWF antigen (vWF:Ag) in the acute period of the disease in pregnant women with COVID-19 was significantly higher compared to the control group (p < 0.001). ADAMTS-13 level in pregnant women after COVID-19 did not differ from that of in control group, while vWF level was significantly higher in 66.7 % (30/45). The ADAMTS-13/vWF ratio was increased and significantly differed both in pregnant patients during the acute period of the disease (p < 0.001) and pregnant women after infection (p = 0.0002) compared with the control group. Conclusion. Our results show that endotheliopathy was prominently manifested in pregnant women with COVID-19 and persisted for several months after disease. The ADAMTS-13/vWF ratio determines the pathway functioning, the risk of microcirculation disorders and clinical complications. |
| format | Article |
| id | doaj-art-e10a9c7e62b1488ebe6bf8e9e9fe78d1 |
| institution | Matheson Library |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2023-03-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-e10a9c7e62b1488ebe6bf8e9e9fe78d12025-08-03T19:55:17ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942023-03-0117181710.17749/2313-7347/ob.gyn.rep.2023.386784Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant womenN. R. Gashimova0K. N. Grigoreva1V. O. Bitsadze2L. L. Pankratyeva3J. Kh. Khizroeva4M. V. Tretyakova5Ya. M. Shammut6E. Iu. Iupatov7V. I. Tsibizova8J.-K. Gris9D. V. Blinov10A. D. Makatsariya11Sechenov UniversitySechenov UniversitySechenov UniversityDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Health Ministry of Russian Federation; Vorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentSechenov UniversitySechenov UniversitySechenov UniversityKazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation; Kazan (Volga Region) Federal UniversityAlmazov National Medical Research Centre, Health Ministry of Russian FederationSechenov University; University of MontpellierSechenov University; Institute for Preventive and Social Medicine; Moscow Haass Medical – Social InstituteSechenov UniversityIntroduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel–Palade bodies, which can affect activity of ADAMTS-13 metalloproteinase (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) and the ADAMTS-13/vWF axis previously shown by us to be altered in non-pregnant women with severe COVID-19. Aim: to study a clinical role of hemostasis activation particularly ADAMTS-13/vWF axis in pregnant women after COVID-19. Materials and Methods. A prospective case–control study was conducted with pregnant women (n = 135) divided into 3 groups: group 1 included 45 women with prior COVID-19 during pregnancy, group 2 – 45 women in the acute phase of the infection during pregnancy, group 3 – 45 healthy pregnant women. The level of vWF and ADAMTS-13 was assessed in all patients. Results. The concentration of vWF antigen (vWF:Ag) in the acute period of the disease in pregnant women with COVID-19 was significantly higher compared to the control group (p < 0.001). ADAMTS-13 level in pregnant women after COVID-19 did not differ from that of in control group, while vWF level was significantly higher in 66.7 % (30/45). The ADAMTS-13/vWF ratio was increased and significantly differed both in pregnant patients during the acute period of the disease (p < 0.001) and pregnant women after infection (p = 0.0002) compared with the control group. Conclusion. Our results show that endotheliopathy was prominently manifested in pregnant women with COVID-19 and persisted for several months after disease. The ADAMTS-13/vWF ratio determines the pathway functioning, the risk of microcirculation disorders and clinical complications.https://www.gynecology.su/jour/article/view/1560pregnancycovid-19adamts-13von willebrand factorvwf |
| spellingShingle | N. R. Gashimova K. N. Grigoreva V. O. Bitsadze L. L. Pankratyeva J. Kh. Khizroeva M. V. Tretyakova Ya. M. Shammut E. Iu. Iupatov V. I. Tsibizova J.-K. Gris D. V. Blinov A. D. Makatsariya Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women Акушерство, гинекология и репродукция pregnancy covid-19 adamts-13 von willebrand factor vwf |
| title | Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women |
| title_full | Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women |
| title_fullStr | Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women |
| title_full_unstemmed | Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women |
| title_short | Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women |
| title_sort | clinical significance of assessing adamts 13 and von willebrand factor level in covid 19 convalescent pregnant women |
| topic | pregnancy covid-19 adamts-13 von willebrand factor vwf |
| url | https://www.gynecology.su/jour/article/view/1560 |
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