Impact of HbA1c levels on coronary SYNTAX score in non-diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty: A cross-sectional study
Background: Glycated hemoglobin A1c (HbA1c) level is related to increased cardiovascular diseases (CVDs) and death, even in non-diabetic subjects. Although in ST-elevation myocardial infarction (STEMI) cases, the association between HbA1c and coronary artery disease (CAD) remains unclear. Methods:...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Babol University of Medical Sciences
2025-06-01
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| Series: | Caspian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://caspjim.com/article-1-4249-en.pdf |
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| Summary: | Background: Glycated hemoglobin A1c (HbA1c) level is related to increased cardiovascular diseases (CVDs) and death, even in non-diabetic subjects. Although in ST-elevation myocardial infarction (STEMI) cases, the association between HbA1c and coronary artery disease (CAD) remains unclear.
Methods: This cross-sectional study was conducted on 167 non-diabetic STEMI patients undergoing primary percutaneous coronary intervention (PCI). The SYNTAX score was utilized to evaluate CAD severity. Cases were categorized into three groups based on the HbA1c levels: <5%, 5.1-5.9%, and 6-6.5%.
Results: SYNTAX scores significantly increased in the cases with 6 to 6.5 HbA1c levels compared to the other group (28.9±9.5 vs 21.2±5.2 vs 13.7±4.5, P=0.000). Additionally, death was more elevated in this group (4% vs 0% vs 0%, P=0.006).
Conclusion: Higher HbA1c levels are strongly associated with coronary atherosclerosis in non-diabetic patients that present with non-diabetic STEMI. Consequently, in non-diabetic STEMI patients, HbA1c may be able to predict the severity of CAD. |
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| ISSN: | 2008-6164 2008-6172 |