Gut Microbiota Modulates Obesity‐Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion

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Gut Microbiota Modulates Obesity‐Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion

Abstract Obesity is associated with skeletal deterioration and increased fracture risk, but the underlying mechanism is unclear. Herein, it is shown that obese gut microbiota promotes skeletal deterioration by inducing bone marrow macrophages (BMMs) senescence and grancalcin (GCA) secretion. Obese m...

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Autori principali:	Min Huang, Mei Huang, Ling Liu, Fang Yang, Chen He, Yu‐Chen Sun, Yu‐Rui Jiao, Xiang Tang, Jing Hou, Kai‐Xuan Chen, Wen‐Zhen He, Jie Wei, Hui‐Ling Chen, Xia Li, Chao Zeng, Guang‐Hua Lei, Chang‐Jun Li
Natura:	Articolo
Lingua:	inglese
Pubblicazione:	Wiley 2025-07-01
Serie:	Advanced Science
Soggetti:	obesity skeletal deterioration immunosenescence grancalcin gut‐microbiota
Accesso online:	https://doi.org/10.1002/advs.202502634
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!

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