Estimating global antibiotic needs for chronic obstructive pulmonary disease and community- and hospital-acquired pneumonia in 20 countries: A modelling analysis
Introduction: Antibiotic stewardship advocates for prudent antibiotic use. However, estimates of “appropriate” antibiotic use remain limited. Methods: We estimated the total antibiotics required to treat chronic obstructive pulmonary disease (COPD) exacerbations and pneumonia in 2019 across the 20 m...
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Elsevier
2025-09-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971225001730 |
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| author | Amit Summan Katherine Klemperer Erta Kalanxhi Anthony McDonnell Ramanan Laxminarayan |
| author_facet | Amit Summan Katherine Klemperer Erta Kalanxhi Anthony McDonnell Ramanan Laxminarayan |
| author_sort | Amit Summan |
| collection | DOAJ |
| description | Introduction: Antibiotic stewardship advocates for prudent antibiotic use. However, estimates of “appropriate” antibiotic use remain limited. Methods: We estimated the total antibiotics required to treat chronic obstructive pulmonary disease (COPD) exacerbations and pneumonia in 2019 across the 20 most populous countries. Antibiotic needs were determined according to World Health Organization AWaRe guidelines. The proportion of cases requiring antibiotics was based on bacterial etiology averages. Patients not responding to first-line treatment were assumed to either recover after second-line treatment, discontinue further care, or die during treatment. Where two treatment options were available, patients were assumed to be evenly split. Results: Penicillins (76.1%) and cephalosporins (22.6%) were the most frequently needed antibiotics for treatment of community-acquired pneumonia, followed by hospital-acquired pneumonia and COPD exacerbations. India and China were estimated as the greatest consumers of penicillins (37% and 21% of total use, respectively), followed by the US, Brazil, and Indonesia (15% combined). Per capita penicillin consumption was highest in India, Brazil, and Germany. In total, 2276,046 and 676,098 million mg of penicillins and cephalosporins, respectively, were needed. Conclusion: Prudent antibiotic use is essential to curb antimicrobial resistance. This framework offers a method for estimating needs and informing global planning. |
| format | Article |
| id | doaj-art-e0d06a47394b49b1901747b727a45b93 |
| institution | Matheson Library |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
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| series | International Journal of Infectious Diseases |
| spelling | doaj-art-e0d06a47394b49b1901747b727a45b932025-08-04T04:23:52ZengElsevierInternational Journal of Infectious Diseases1201-97122025-09-01158107949Estimating global antibiotic needs for chronic obstructive pulmonary disease and community- and hospital-acquired pneumonia in 20 countries: A modelling analysisAmit Summan0Katherine Klemperer1Erta Kalanxhi2Anthony McDonnell3Ramanan Laxminarayan4One Health Trust, Washington, DC, USA; Economics for Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Corresponding author at: Amit Summan, One Health Trust, 5636 Connecticut Avenue NW, PO Box 42735, Washington, DC 20015, USA.Center for Global Development, London, UKOne Health Trust, Washington, DC, USACenter for Global Development, London, UKOne Health Trust, New Delhi, India; High Meadows Environmental Institute, Princeton University, Princeton, NJ, USAIntroduction: Antibiotic stewardship advocates for prudent antibiotic use. However, estimates of “appropriate” antibiotic use remain limited. Methods: We estimated the total antibiotics required to treat chronic obstructive pulmonary disease (COPD) exacerbations and pneumonia in 2019 across the 20 most populous countries. Antibiotic needs were determined according to World Health Organization AWaRe guidelines. The proportion of cases requiring antibiotics was based on bacterial etiology averages. Patients not responding to first-line treatment were assumed to either recover after second-line treatment, discontinue further care, or die during treatment. Where two treatment options were available, patients were assumed to be evenly split. Results: Penicillins (76.1%) and cephalosporins (22.6%) were the most frequently needed antibiotics for treatment of community-acquired pneumonia, followed by hospital-acquired pneumonia and COPD exacerbations. India and China were estimated as the greatest consumers of penicillins (37% and 21% of total use, respectively), followed by the US, Brazil, and Indonesia (15% combined). Per capita penicillin consumption was highest in India, Brazil, and Germany. In total, 2276,046 and 676,098 million mg of penicillins and cephalosporins, respectively, were needed. Conclusion: Prudent antibiotic use is essential to curb antimicrobial resistance. This framework offers a method for estimating needs and informing global planning.http://www.sciencedirect.com/science/article/pii/S1201971225001730Antibiotic stewardshipAntimicrobial resistancePneumoniaCOPD |
| spellingShingle | Amit Summan Katherine Klemperer Erta Kalanxhi Anthony McDonnell Ramanan Laxminarayan Estimating global antibiotic needs for chronic obstructive pulmonary disease and community- and hospital-acquired pneumonia in 20 countries: A modelling analysis International Journal of Infectious Diseases Antibiotic stewardship Antimicrobial resistance Pneumonia COPD |
| title | Estimating global antibiotic needs for chronic obstructive pulmonary disease and community- and hospital-acquired pneumonia in 20 countries: A modelling analysis |
| title_full | Estimating global antibiotic needs for chronic obstructive pulmonary disease and community- and hospital-acquired pneumonia in 20 countries: A modelling analysis |
| title_fullStr | Estimating global antibiotic needs for chronic obstructive pulmonary disease and community- and hospital-acquired pneumonia in 20 countries: A modelling analysis |
| title_full_unstemmed | Estimating global antibiotic needs for chronic obstructive pulmonary disease and community- and hospital-acquired pneumonia in 20 countries: A modelling analysis |
| title_short | Estimating global antibiotic needs for chronic obstructive pulmonary disease and community- and hospital-acquired pneumonia in 20 countries: A modelling analysis |
| title_sort | estimating global antibiotic needs for chronic obstructive pulmonary disease and community and hospital acquired pneumonia in 20 countries a modelling analysis |
| topic | Antibiotic stewardship Antimicrobial resistance Pneumonia COPD |
| url | http://www.sciencedirect.com/science/article/pii/S1201971225001730 |
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