Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles

QR Code

Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles

Aim. Selection, synthesis and biological properties of new compound play major role in creating original medicines. Methods and results. Therefore, to find new bioactive compounds 3-(alkylthio)-4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles, where R - methyl, ethyl, phenyl, have been synthesized...

Full description

Saved in:

Bibliographic Details
Main Authors:	O. A. Suhak, O. I. Panasenko, Ye. G. Knysh
Format:	Article
Language:	English
Published:	Zaporizhzhia State Medical and Pharmaceutical University 2015-08-01
Series:	Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Subjects:	1 2 4-triazoles IR-spectroscopy HPLC-mass Spectrometry Synthesis
Online Access:	http://pharmed.zsmu.edu.ua/article/view/45130/43759
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis and properties of bis((4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)alkanes
by: O. A. Suhak, et al.
Published: (2018-08-01)

Antibacterial and antifungal activity of derivatives 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole
by: O. A. Suhak, et al.
Published: (2015-12-01)

Synthesis, physical-chemical properties of 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides
by: O. A. Suhak, et al.
Published: (2017-04-01)

Acute toxicity of S-derivatives of 4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles
by: O. A. Suhak, et al.
Published: (2017-12-01)

Antihypoxic activity of benzylidenhydrazides of 4-R-5- (thiophene-2-ylmethyl)-1,2,4-triazol-3-il)thioacetic acid
by: O. A. Suhak, et al.
Published: (2017-08-01)

Investigation of diuretic activity of 4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles’ derivatives
by: O. A. Suhak, et al.
Published: (2018-03-01)

Synthesis, physical and chemical properties of 2-((4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetic acids salts
by: А.А. Safonov, et al.
Published: (2017-12-01)

Synthesis, physical and chemical research of alkyl-, heterylderivatives of 7'-((4-ethyl-5-thio-4H-1,2,4-triazoles-3-yl)methyl)theophylline
by: A. S. Gotsulya
Published: (2016-08-01)

Synthesis, physical and chemical properties, antihypoxic activity of some 5-[((5-(adamantane-1-yl)-4-R-4H-1,2,4-triazole-3-yl)thio)methyl]-N-R1-1,3,4-thiadiazole-2-amines and 5-[((5-(adamantane-1-yl)-4-R-4H-1,2,4-triazole-3-yl)thio)methyl]-4-R1-4H-1,2,4-t
by: V. M. Odyntsova, et al.
Published: (2018-03-01)

Synthesis of 5-(phenoxymethyl)-4-R-alkylthio-1,2,4-triazoles and its further oxidation to 3-alkylsulfonylderivatives
by: Yu. M. Kucheryavyi, et al.
Published: (2015-12-01)

Synthesis, antimicrobial and antifungal activity of 3-(2-bromophenyl)-5-(alkylthio)-4-phenyl-4H-1,2,4-triazoles
by: A. A. Safonov, et al.
Published: (2022-12-01)

Antiradical activity of novel 4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol derivatives
by: A. A. Safonov, et al.
Published: (2021-07-01)

Synthesis, physical and chemical properties of esters of 2-((5-(hydroxy(phenyl)methyl)-4-R-1,2,4-triazole-3-yl)thio)ethanoic and 3-(((5-(hydroxy(phenyl)methyl)-4-R-1,2,4-triazole-3-yl)thio)methyl)benzoic acids
by: А. M. Rud, et al.
Published: (2017-12-01)

Anti-tuberculosis activity research of 5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol
by: A. A. Safonov, et al.
Published: (2019-12-01)

Synthesis and physical-chemical properties of 2-((4-R-3-(morpholinomethylen)-4H-1,2,4-triazole-5yl)thio)acetic acid
by: R. О. Shcherbyna, et al.
Published: (2014-12-01)

Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol
by: I. I. Aksionova, et al.
Published: (2015-08-01)

Investigation of physical and chemical properties of new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols
by: A. V. Khilkovets
Published: (2021-07-01)

Synthesis and physical-chemical properties of 3-(4-(tert-butyl)phenyl)-5-(R-ylthio)-4H-1,2,4-triazol-4-amines
by: I. I. Aksyonova, et al.
Published: (2016-04-01)

Study of the effect of sodium 2-((4-amino-5-(thiophen-2-ylmethyl)- 4H-1,2,4-triazole-3-yl)thio)acetate toxic doses on rats heart tissue
by: A. A. Safonov, et al.
Published: (2024-06-01)

In silico study of new bis-3R, 4R′-5-(((1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thione derivatives
by: Ye. O. Karpun, et al.
Published: (2019-12-01)

Synthesis, physical and chemical properties of 3-((5-(hydroxy(phenyl)methine)-4-R-4H-1,2,4-triazole-3-yl)thio)aceto(propane, methylene-о-, m-, p-benzo)nitriles
by: А. M. Rud, et al.
Published: (2016-12-01)

A study of actoprotective activity of new 3-(thiophen-2-ylmethyl)-1H-1,2,4-triazole-5-thiol derivatives
by: A. A. Safonov
Published: (2020-11-01)

Synthesis and physical-chemical properties of 2-(5-(1Н-tetrazol-1-ylmethyl)-4-R-4Н-1,2,4-triazol-3-yltio)-acetic (propanoic), 2-, 4-(5-(1Н-tetrazol-1- ylmethyl)-4-phenyl-4Н-1,2,4-triazol-3- yltiometil)-benzoic acids and their salts
by: Y. S. Hulina, et al.
Published: (2016-08-01)

Establishment of diuretic activity indicators for (3-thio-4-R-4-H-1,2,4-triazole-5-yl)(phenyl)methanols and their derivatives
by: A. M. Rud, et al.
Published: (2018-08-01)

Determination of the isotonicity 1 % solution of sodium 2-((4-amino-5-thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetate
by: D. L. Usenko, et al.
Published: (2024-02-01)

Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines
by: Ye. O. Karpun, et al.
Published: (2020-11-01)

Synthesis and analgesic activity of new pyrazole-containing derivatives of 1,2,4-triazole-3-thiol
by: S. O. Fedotov, et al.
Published: (2023-11-01)

The search of new biologically active compounds with antibacterial and antifungal activity among 1,2,4-triazole-3-thiol derivatives with the remnants of thiophene
by: V. O. Salionov, et al.
Published: (2017-08-01)

Analgesic activity of 4-amino-5-methyl-4H-1,2,4-triazol-3-thiones
by: T. V. Kravchenko, et al.
Published: (2018-10-01)

Chemical properties of amino- and thio-derivatives of 1,2,4-triazoles
by: A. G. Kaplaushenko
Published: (2015-04-01)

Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives
by: O. A. Bihdan, et al.
Published: (2017-08-01)

Synthesis, physical and chemical properties of 2-((4-R-3-(morfolinomethylen)-4H-1,2,4-triazole-5-yl)thio)acetic acid salts
by: R. О. Shcherbyna
Published: (2017-04-01)

Development of determination method and study of piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio) acetate in milk of cows in 12 hours after administration
by: B. O. Varynskyi, et al.
Published: (2019-07-01)

Anti-inflammatory activity of 2-(5-((theophylline-7'-yl)methyl)-4-R-4H-1,2,4-triazole-3-ylthio)acetic acid salts
by: A. S. Gotsulya, et al.
Published: (2014-12-01)

The research of acute toxicity of 4-amino-5-(4-(tert-butyl)phenyl)-4H-1,2,4-triazoles-3-thiol derivatives
by: I. I. Аksyonova-Seliuk, et al.
Published: (2017-08-01)

Synthesis and structure of new 4-amino-5-(2-R1-phenyl)-1,2,4-triazole-3-thiol alkilderivatives
by: Ye. S. Pruglo
Published: (2017-08-01)

Discussion of antimicrobial and antifungal activity of 4-amino-5-methyl-4H-1,2,4-triazole-3-thiol
by: T. V. Kravchenko, et al.
Published: (2017-04-01)

Diuretic activity of 3-(5-bromfuran-2-yl)-4-r-(4h)-1,2,4-triazole-5-thione, their S-derivatives and 2-(5-bromfuran-2-yl)-5-r'-thiazolo[3,2-b][1,2,4]triazole-6(5h)-ones
by: Ye. S. Pruglo, et al.
Published: (2015-12-01)

Synthesis and structure of salts of 2-(((3-mercapto-5-methyl-4H-1,2,4-triazole-4-yl)imino)methyl)benzoic acid
by: T. V. Hlazunova
Published: (2020-05-01)

Acute toxicity of 2-(5-(adamantane-1-yl)-4R-1,2,4-triazole-3-ylthio) of the acetic acids and their salts’ derivatives
by: V. M. Odyntsova, et al.
Published: (2015-12-01)