Identification of novel drug targets for primary open angle glaucoma and its potential side-effects by human plasma proteome

Identification of novel drug targets for primary open angle glaucoma and its potential side-effects by human plasma proteome

AIM: To explore whether plasma proteins serve as potential therapeutic targets for primary open angle glaucoma (POAG) based on a Mendelian randomization (MR) study. METHODS: Large-scale protein quantitative trait loci (pQTLs) data from the Icelandic deCODE database and two large POAG Genome-Wide Ass...

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Bibliographic Details
Main Authors: Da-Dong Jia, Qing-Ao Xiao, Shi-Yi Song, Meng Pan, Hao Hu, Kai-Li Wu, Jia-Bing Ran, Liang Liang
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2025-08-01
Series:International Journal of Ophthalmology
Subjects:
drug targets
mendelian randomization
proteome-wide mendelian randomization
primary open angle glaucoma
Online Access:http://ies.ijo.cn/en_publish/2025/8/20250807.pdf
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