Practical steps to develop a transcriptomic test for blood doping
Blood doping remains a significant problem that threatens the integrity of sport. The current indirect method for detecting blood doping involves the longitudinal measurement of an athlete’s haematological variables and identification of suspicious results that are indicative of doping (i.e., the at...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-07-01
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| Series: | Translational Exercise Biomedicine |
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| Online Access: | https://doi.org/10.1515/teb-2024-0010 |
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| _version_ | 1839581897925066752 |
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| author | Sutehall Shaun Malinsky Fernanda Voss Sven Chester Neil Xu Xiao Pitsiladis Yannis |
| author_facet | Sutehall Shaun Malinsky Fernanda Voss Sven Chester Neil Xu Xiao Pitsiladis Yannis |
| author_sort | Sutehall Shaun |
| collection | DOAJ |
| description | Blood doping remains a significant problem that threatens the integrity of sport. The current indirect method for detecting blood doping involves the longitudinal measurement of an athlete’s haematological variables and identification of suspicious results that are indicative of doping (i.e., the athlete biological passport). While this has played a significant role in the protection of clean sport, improvements are needed. The development of a transcriptomic test, that can be used to detect the use of blood doping has been discussed and researched for decades and yet, an anti-doping test that can be adopted by the World Anti-Doping Agency (WADA) is yet to be established. With recent advancements in our understanding, as well as in methods of sample collection, the possibility of a transcriptomic test that can be used by WADA, is imminent. There are, however, several practical considerations that must first be made, that will be highlighted in this perspective article. |
| format | Article |
| id | doaj-art-dfff7ccb823e4459be8d4e24e84e1ba6 |
| institution | Matheson Library |
| issn | 2942-6812 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Exercise Biomedicine |
| spelling | doaj-art-dfff7ccb823e4459be8d4e24e84e1ba62025-08-04T09:40:07ZengDe GruyterTranslational Exercise Biomedicine2942-68122024-07-011210511010.1515/teb-2024-0010Practical steps to develop a transcriptomic test for blood dopingSutehall Shaun0Malinsky Fernanda1Voss Sven2Chester Neil3Xu Xiao4Pitsiladis Yannis5Clincial Research Division, Alder Hey Children’s NHS Foundation Trust, Liverpool, UKDepartment of Sport and Health Sciences, Hong Kong Baptist University, Hong Kong, ChinaInstitute of Doping Analysis and Sport Biochemistry, Kreischa, GermanyResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UKMGI Tech, Shenzhen, ChinaDepartment of Sport and Health Sciences, Hong Kong Baptist University, Hong Kong, ChinaBlood doping remains a significant problem that threatens the integrity of sport. The current indirect method for detecting blood doping involves the longitudinal measurement of an athlete’s haematological variables and identification of suspicious results that are indicative of doping (i.e., the athlete biological passport). While this has played a significant role in the protection of clean sport, improvements are needed. The development of a transcriptomic test, that can be used to detect the use of blood doping has been discussed and researched for decades and yet, an anti-doping test that can be adopted by the World Anti-Doping Agency (WADA) is yet to be established. With recent advancements in our understanding, as well as in methods of sample collection, the possibility of a transcriptomic test that can be used by WADA, is imminent. There are, however, several practical considerations that must first be made, that will be highlighted in this perspective article.https://doi.org/10.1515/teb-2024-0010anti-dopingtestingblood dopingepotranscriptomics |
| spellingShingle | Sutehall Shaun Malinsky Fernanda Voss Sven Chester Neil Xu Xiao Pitsiladis Yannis Practical steps to develop a transcriptomic test for blood doping Translational Exercise Biomedicine anti-doping testing blood doping epo transcriptomics |
| title | Practical steps to develop a transcriptomic test for blood doping |
| title_full | Practical steps to develop a transcriptomic test for blood doping |
| title_fullStr | Practical steps to develop a transcriptomic test for blood doping |
| title_full_unstemmed | Practical steps to develop a transcriptomic test for blood doping |
| title_short | Practical steps to develop a transcriptomic test for blood doping |
| title_sort | practical steps to develop a transcriptomic test for blood doping |
| topic | anti-doping testing blood doping epo transcriptomics |
| url | https://doi.org/10.1515/teb-2024-0010 |
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