Results of the nerve-sparing radical prostatectomy in obese patients
Introduction. According to several studies, an increased body mass index (BMI) may be one of the unfavorable prognostic factors of prostate cancer (PC) associated with lower oncological and functional outcomes of radical prostatectomy (RP).Purpose of the study. To evaluate pathomorphological charact...
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Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education
2020-07-01
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| Series: | Вестник урологии |
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| Online Access: | https://www.urovest.ru/jour/article/view/329 |
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| author | E. A. Sokolov E. I. Veliev |
| author_facet | E. A. Sokolov E. I. Veliev |
| author_sort | E. A. Sokolov |
| collection | DOAJ |
| description | Introduction. According to several studies, an increased body mass index (BMI) may be one of the unfavorable prognostic factors of prostate cancer (PC) associated with lower oncological and functional outcomes of radical prostatectomy (RP).Purpose of the study. To evaluate pathomorphological characteristics, recurrence-free survival, and restoration of erectile function (EF) after RP with nerve-sparing technique (NST) in obese patients.Materials and methods. The study group consisted of 91 patients with BMI ≥ 30 kg/m2 , the control group consisted of 356 patients with BMI < 30 kg/m2 who underwent RP with unilateral or bilateral NST from January 2012 to December 2019. A comparative analysis of pathomorphological results, the rate of complications, recurrence-free survival, and the dynamics of EF restoration in both groups was performed.Results. Obese patients had a larger prostate volume, a higher score for the International Prostate Symptom Score (IPSS) questionnaire. Unilateral and bilateral NST was used in both groups in equal proportions: 50.5% and 49.5% in the group with BMI ≥ 30 and 51.4% and 48.6% in the group with BMI < 30 (p = 0.88 ) There were no significant differences between the groups in the rate of adverse pathomorphological characteristics, serious postoperative complications and the volume of intraoperative blood loss. The five-year recurrence-free survival after RP was 93.1% in the BMI group ≥ 30 and 95.1% in the BMI group < 30 (p = 0.55). The total rate of EF recovery after RP with NST after 24 months was 75% and 78.5% (p = 0.24). The restoration of EF in obese patients was slower: sufficient for sexual intercourse EF after 6 and 12 months was observed in 17.9% and 32.1% versus 35.4% and 53.8% in the group with BMI < 30, and the meantime to recovery was 10.9 (± 1) and 8.6 (± 0.6) months, respectively (p = 0.04).Conclusions. Obesity does not affect the pathomorphological and oncological results of RP with NST. EF recovery in patients with a BMI of ≥ 30 is slowed down, however, 24 months after surgery, the results are comparable with the potency level in patients with a BMI < 30. The data obtained may be of value in counselling and planning surgical intervention in obese patients with PC. |
| format | Article |
| id | doaj-art-dfdd7cc97a60497783cfaaf7a3db2eca |
| institution | Matheson Library |
| issn | 2308-6424 |
| language | Russian |
| publishDate | 2020-07-01 |
| publisher | Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education |
| record_format | Article |
| series | Вестник урологии |
| spelling | doaj-art-dfdd7cc97a60497783cfaaf7a3db2eca2025-08-04T12:51:14ZrusMinistry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional EducationВестник урологии2308-64242020-07-0182434910.21886/2308-6424-2020-8-2-43-49243Results of the nerve-sparing radical prostatectomy in obese patientsE. A. Sokolov0E. I. Veliev1Russian Medical Academy of Continuing Professional Education; S.P. Botkin State Clinical HospitalRussian Medical Academy of Continuing Professional Education; S.P. Botkin State Clinical HospitalIntroduction. According to several studies, an increased body mass index (BMI) may be one of the unfavorable prognostic factors of prostate cancer (PC) associated with lower oncological and functional outcomes of radical prostatectomy (RP).Purpose of the study. To evaluate pathomorphological characteristics, recurrence-free survival, and restoration of erectile function (EF) after RP with nerve-sparing technique (NST) in obese patients.Materials and methods. The study group consisted of 91 patients with BMI ≥ 30 kg/m2 , the control group consisted of 356 patients with BMI < 30 kg/m2 who underwent RP with unilateral or bilateral NST from January 2012 to December 2019. A comparative analysis of pathomorphological results, the rate of complications, recurrence-free survival, and the dynamics of EF restoration in both groups was performed.Results. Obese patients had a larger prostate volume, a higher score for the International Prostate Symptom Score (IPSS) questionnaire. Unilateral and bilateral NST was used in both groups in equal proportions: 50.5% and 49.5% in the group with BMI ≥ 30 and 51.4% and 48.6% in the group with BMI < 30 (p = 0.88 ) There were no significant differences between the groups in the rate of adverse pathomorphological characteristics, serious postoperative complications and the volume of intraoperative blood loss. The five-year recurrence-free survival after RP was 93.1% in the BMI group ≥ 30 and 95.1% in the BMI group < 30 (p = 0.55). The total rate of EF recovery after RP with NST after 24 months was 75% and 78.5% (p = 0.24). The restoration of EF in obese patients was slower: sufficient for sexual intercourse EF after 6 and 12 months was observed in 17.9% and 32.1% versus 35.4% and 53.8% in the group with BMI < 30, and the meantime to recovery was 10.9 (± 1) and 8.6 (± 0.6) months, respectively (p = 0.04).Conclusions. Obesity does not affect the pathomorphological and oncological results of RP with NST. EF recovery in patients with a BMI of ≥ 30 is slowed down, however, 24 months after surgery, the results are comparable with the potency level in patients with a BMI < 30. The data obtained may be of value in counselling and planning surgical intervention in obese patients with PC.https://www.urovest.ru/jour/article/view/329prostate cancerradical prostatectomyobesityerectile functionnerve-sparing technique |
| spellingShingle | E. A. Sokolov E. I. Veliev Results of the nerve-sparing radical prostatectomy in obese patients Вестник урологии prostate cancer radical prostatectomy obesity erectile function nerve-sparing technique |
| title | Results of the nerve-sparing radical prostatectomy in obese patients |
| title_full | Results of the nerve-sparing radical prostatectomy in obese patients |
| title_fullStr | Results of the nerve-sparing radical prostatectomy in obese patients |
| title_full_unstemmed | Results of the nerve-sparing radical prostatectomy in obese patients |
| title_short | Results of the nerve-sparing radical prostatectomy in obese patients |
| title_sort | results of the nerve sparing radical prostatectomy in obese patients |
| topic | prostate cancer radical prostatectomy obesity erectile function nerve-sparing technique |
| url | https://www.urovest.ru/jour/article/view/329 |
| work_keys_str_mv | AT easokolov resultsofthenervesparingradicalprostatectomyinobesepatients AT eiveliev resultsofthenervesparingradicalprostatectomyinobesepatients |