MULTIPLEX ANALYSIS OF PERIPHERAL BIOMARKERS IN SCHIZOPHRENIC PATIENTS WITH LONG-TERM ANTIPSYCHOTIC THERAPY
Complex clinical and biological study of 115 schizophrenic patients with long-term antipsychotic treatment was carried out. Concentrations of brain-derived neurotrophic factor (BDNF) and prolactin levels in blood serum in schizophrenic patients and healthy subjects were determined to multiplex analy...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/177 |
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| _version_ | 1839586810066370560 |
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| author | A. S. Boiko I. S. Losenkov E. G. Dmitrieva |
| author_facet | A. S. Boiko I. S. Losenkov E. G. Dmitrieva |
| author_sort | A. S. Boiko |
| collection | DOAJ |
| description | Complex clinical and biological study of 115 schizophrenic patients with long-term antipsychotic treatment was carried out. Concentrations of brain-derived neurotrophic factor (BDNF) and prolactin levels in blood serum in schizophrenic patients and healthy subjects were determined to multiplex analyzer MAGPIX (Luminex, USA) using the kits MILLIPLEX® MAP (Merck, Germany). BDNF concentration was significantly correlated with the severity of positive symptoms in schizophrenic patients. Antipsychotics induced hyperprolactinemia is the need to monitor the level of prolactin to develop personalized approaches to treatment and improve the quality of life of patients. |
| format | Article |
| id | doaj-art-df71a9862e8146539d56a341ee610f90 |
| institution | Matheson Library |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-df71a9862e8146539d56a341ee610f902025-08-03T19:23:53ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0104212217177MULTIPLEX ANALYSIS OF PERIPHERAL BIOMARKERS IN SCHIZOPHRENIC PATIENTS WITH LONG-TERM ANTIPSYCHOTIC THERAPYA. S. Boiko0I. S. Losenkov1E. G. Dmitrieva2Mental Health Research Institute, Tomsk national research medical center of the Russian Academy of SciencesMental Health Research Institute, Tomsk national research medical center of the Russian Academy of SciencesMental Health Research Institute, Tomsk national research medical center of the Russian Academy of SciencesComplex clinical and biological study of 115 schizophrenic patients with long-term antipsychotic treatment was carried out. Concentrations of brain-derived neurotrophic factor (BDNF) and prolactin levels in blood serum in schizophrenic patients and healthy subjects were determined to multiplex analyzer MAGPIX (Luminex, USA) using the kits MILLIPLEX® MAP (Merck, Germany). BDNF concentration was significantly correlated with the severity of positive symptoms in schizophrenic patients. Antipsychotics induced hyperprolactinemia is the need to monitor the level of prolactin to develop personalized approaches to treatment and improve the quality of life of patients.https://www.pharmjournal.ru/jour/article/view/177brain-derived neurotrophic factorprolactinschizophreniamultiplex analysisantipsychotic therapy |
| spellingShingle | A. S. Boiko I. S. Losenkov E. G. Dmitrieva MULTIPLEX ANALYSIS OF PERIPHERAL BIOMARKERS IN SCHIZOPHRENIC PATIENTS WITH LONG-TERM ANTIPSYCHOTIC THERAPY Разработка и регистрация лекарственных средств brain-derived neurotrophic factor prolactin schizophrenia multiplex analysis antipsychotic therapy |
| title | MULTIPLEX ANALYSIS OF PERIPHERAL BIOMARKERS IN SCHIZOPHRENIC PATIENTS WITH LONG-TERM ANTIPSYCHOTIC THERAPY |
| title_full | MULTIPLEX ANALYSIS OF PERIPHERAL BIOMARKERS IN SCHIZOPHRENIC PATIENTS WITH LONG-TERM ANTIPSYCHOTIC THERAPY |
| title_fullStr | MULTIPLEX ANALYSIS OF PERIPHERAL BIOMARKERS IN SCHIZOPHRENIC PATIENTS WITH LONG-TERM ANTIPSYCHOTIC THERAPY |
| title_full_unstemmed | MULTIPLEX ANALYSIS OF PERIPHERAL BIOMARKERS IN SCHIZOPHRENIC PATIENTS WITH LONG-TERM ANTIPSYCHOTIC THERAPY |
| title_short | MULTIPLEX ANALYSIS OF PERIPHERAL BIOMARKERS IN SCHIZOPHRENIC PATIENTS WITH LONG-TERM ANTIPSYCHOTIC THERAPY |
| title_sort | multiplex analysis of peripheral biomarkers in schizophrenic patients with long term antipsychotic therapy |
| topic | brain-derived neurotrophic factor prolactin schizophrenia multiplex analysis antipsychotic therapy |
| url | https://www.pharmjournal.ru/jour/article/view/177 |
| work_keys_str_mv | AT asboiko multiplexanalysisofperipheralbiomarkersinschizophrenicpatientswithlongtermantipsychotictherapy AT islosenkov multiplexanalysisofperipheralbiomarkersinschizophrenicpatientswithlongtermantipsychotictherapy AT egdmitrieva multiplexanalysisofperipheralbiomarkersinschizophrenicpatientswithlongtermantipsychotictherapy |