Study of chronic toxicity of the GB-115 drug formulation
The results of the study of chronic toxicity of the drug formulation of anxiolytic GB-115 are presented. The novel dipeptide in the form of a tablet mass was administered daily orally for 6 months to outbred rats and rabbits of the chinchilla breed at a dose of 1 mg/kg corresponding to the therapeut...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2020-04-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/230 |
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| author | A. V. Sorokina S. V. Alekseeva I. A. Miroshkina V. V. Zabrodina L. G. Kolik A. D. Durnev |
| author_facet | A. V. Sorokina S. V. Alekseeva I. A. Miroshkina V. V. Zabrodina L. G. Kolik A. D. Durnev |
| author_sort | A. V. Sorokina |
| collection | DOAJ |
| description | The results of the study of chronic toxicity of the drug formulation of anxiolytic GB-115 are presented. The novel dipeptide in the form of a tablet mass was administered daily orally for 6 months to outbred rats and rabbits of the chinchilla breed at a dose of 1 mg/kg corresponding to the therapeutic and 50 mg/kg exceeding the therapeutic dose by 50 times. Clinical, laboratory and pathohistological studies performed in accordance with the General Protocol demonstrated the absence of toxic effects of the GB-115 drug formulation. The exception was the reversible changes in the coagulation activity in rats and rabbits, which were not associated with the dose of the GB-115 solid dosage from. |
| format | Article |
| id | doaj-art-df4e3a7673394b2fb23c766a1c7ab3d0 |
| institution | Matheson Library |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2020-04-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-df4e3a7673394b2fb23c766a1c7ab3d02025-08-03T13:00:46ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302020-04-0104374410.37489/2587-7836-2019-4-37-44228Study of chronic toxicity of the GB-115 drug formulationA. V. Sorokina0S. V. Alekseeva1I. A. Miroshkina2V. V. Zabrodina3L. G. Kolik4A. D. Durnev5FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»The results of the study of chronic toxicity of the drug formulation of anxiolytic GB-115 are presented. The novel dipeptide in the form of a tablet mass was administered daily orally for 6 months to outbred rats and rabbits of the chinchilla breed at a dose of 1 mg/kg corresponding to the therapeutic and 50 mg/kg exceeding the therapeutic dose by 50 times. Clinical, laboratory and pathohistological studies performed in accordance with the General Protocol demonstrated the absence of toxic effects of the GB-115 drug formulation. The exception was the reversible changes in the coagulation activity in rats and rabbits, which were not associated with the dose of the GB-115 solid dosage from.https://www.pharmacokinetica.ru/jour/article/view/230gb-115solid dosage form (tablets)chronic toxicityratsrabbits |
| spellingShingle | A. V. Sorokina S. V. Alekseeva I. A. Miroshkina V. V. Zabrodina L. G. Kolik A. D. Durnev Study of chronic toxicity of the GB-115 drug formulation Фармакокинетика и Фармакодинамика gb-115 solid dosage form (tablets) chronic toxicity rats rabbits |
| title | Study of chronic toxicity of the GB-115 drug formulation |
| title_full | Study of chronic toxicity of the GB-115 drug formulation |
| title_fullStr | Study of chronic toxicity of the GB-115 drug formulation |
| title_full_unstemmed | Study of chronic toxicity of the GB-115 drug formulation |
| title_short | Study of chronic toxicity of the GB-115 drug formulation |
| title_sort | study of chronic toxicity of the gb 115 drug formulation |
| topic | gb-115 solid dosage form (tablets) chronic toxicity rats rabbits |
| url | https://www.pharmacokinetica.ru/jour/article/view/230 |
| work_keys_str_mv | AT avsorokina studyofchronictoxicityofthegb115drugformulation AT svalekseeva studyofchronictoxicityofthegb115drugformulation AT iamiroshkina studyofchronictoxicityofthegb115drugformulation AT vvzabrodina studyofchronictoxicityofthegb115drugformulation AT lgkolik studyofchronictoxicityofthegb115drugformulation AT addurnev studyofchronictoxicityofthegb115drugformulation |