A cytoderm metabolic labeling TPAPy-Tre for real-time detection of vitality of Mycobacterium tuberculosis in sputum

A cytoderm metabolic labeling TPAPy-Tre for real-time detection of vitality of Mycobacterium tuberculosis in sputum

ABSTRACT Early bactericidal activity is a vital measure in developing new tuberculosis (TB) drugs. Traditional methods, including colony-forming units (CFUs) and time to positivity (TTP), have limitations. This study aimed to evaluate the efficacy of TPAPy-Tre fluorescence microscopy in monitoring e...

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Bibliographic Details
Main Authors: Mengru Yang, Guiqin Dai, Dan Li, Pengfei Zhao, Senlin Zhan, Hongjuan Qin, Hongzhou Lu, Mingbin Zheng, Peize Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
early bactericidal activity (EBA)
tuberculosis (TB)
TPAPy-Tre microscopy
fluorescence intensity
treatment response monitoring
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02457-24
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