Recent progress in microRNA-based delivery systems for the treatment of human disease
Abstract MicroRNAs (miRNAs) are naturally occurring, small non-coding RNAs that mediate posttranscriptional regulation. Based on the level of sequence complementarity, miRNAs lead to the degradation of target mRNAs or the suppression of mRNA translation, thereby inhibiting the synthesis of proteins...
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| Format: | Article |
| Language: | English |
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ELS Publishing (ELSP)
2019-08-01
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| Series: | ExRNA |
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| Online Access: | http://link.springer.com/article/10.1186/s41544-019-0024-y |
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| _version_ | 1839596352320831488 |
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| author | Yong Fu Jiangning Chen Zhen Huang |
| author_facet | Yong Fu Jiangning Chen Zhen Huang |
| author_sort | Yong Fu |
| collection | DOAJ |
| description | Abstract MicroRNAs (miRNAs) are naturally occurring, small non-coding RNAs that mediate posttranscriptional regulation. Based on the level of sequence complementarity, miRNAs lead to the degradation of target mRNAs or the suppression of mRNA translation, thereby inhibiting the synthesis of proteins and achieving the regulation of genes. miRNAs, which exhibit tissue- and temporal- specific expression, are important negative regulatory RNAs that decrease the levels of other functional genes. miRNAs play a crucial role in disease progression and prognosis and thus exhibit potential for developing novel therapeutics. Due to the instability of miRNAs and their complex environment, including degradation by nucleases in vivo, the safety and effectiveness of miRNA delivery has become the focus of recent attention. Therefore, we discuss some representative advances related to the application of viral- and nonviral-mediated miRNA delivery systems and provide a new perspective on the future of miRNA-based therapeutic strategies. |
| format | Article |
| id | doaj-art-df0f52f9d09548f0bd99cea6ec72d6e1 |
| institution | Matheson Library |
| issn | 2398-0060 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | ELS Publishing (ELSP) |
| record_format | Article |
| series | ExRNA |
| spelling | doaj-art-df0f52f9d09548f0bd99cea6ec72d6e12025-08-02T21:22:05ZengELS Publishing (ELSP)ExRNA2398-00602019-08-011111410.1186/s41544-019-0024-yRecent progress in microRNA-based delivery systems for the treatment of human diseaseYong Fu0Jiangning Chen1Zhen Huang2State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing UniversityAbstract MicroRNAs (miRNAs) are naturally occurring, small non-coding RNAs that mediate posttranscriptional regulation. Based on the level of sequence complementarity, miRNAs lead to the degradation of target mRNAs or the suppression of mRNA translation, thereby inhibiting the synthesis of proteins and achieving the regulation of genes. miRNAs, which exhibit tissue- and temporal- specific expression, are important negative regulatory RNAs that decrease the levels of other functional genes. miRNAs play a crucial role in disease progression and prognosis and thus exhibit potential for developing novel therapeutics. Due to the instability of miRNAs and their complex environment, including degradation by nucleases in vivo, the safety and effectiveness of miRNA delivery has become the focus of recent attention. Therefore, we discuss some representative advances related to the application of viral- and nonviral-mediated miRNA delivery systems and provide a new perspective on the future of miRNA-based therapeutic strategies.http://link.springer.com/article/10.1186/s41544-019-0024-ymicroRNAmicroRNA deliveryViral vectorsNonviral vectors |
| spellingShingle | Yong Fu Jiangning Chen Zhen Huang Recent progress in microRNA-based delivery systems for the treatment of human disease ExRNA microRNA microRNA delivery Viral vectors Nonviral vectors |
| title | Recent progress in microRNA-based delivery systems for the treatment of human disease |
| title_full | Recent progress in microRNA-based delivery systems for the treatment of human disease |
| title_fullStr | Recent progress in microRNA-based delivery systems for the treatment of human disease |
| title_full_unstemmed | Recent progress in microRNA-based delivery systems for the treatment of human disease |
| title_short | Recent progress in microRNA-based delivery systems for the treatment of human disease |
| title_sort | recent progress in microrna based delivery systems for the treatment of human disease |
| topic | microRNA microRNA delivery Viral vectors Nonviral vectors |
| url | http://link.springer.com/article/10.1186/s41544-019-0024-y |
| work_keys_str_mv | AT yongfu recentprogressinmicrornabaseddeliverysystemsforthetreatmentofhumandisease AT jiangningchen recentprogressinmicrornabaseddeliverysystemsforthetreatmentofhumandisease AT zhenhuang recentprogressinmicrornabaseddeliverysystemsforthetreatmentofhumandisease |