Clinical pharmacology of the combination of ACE inhibitors and calcium antagonists: benefits of the perindopril arginine and amlodipine combination
The paper reviews the modern evidence on mechanisms of action and clinical effectiveness of two cardiovascular medication classes – angiotensin-converting enzyme (ACE) inhibitors and calcium antagonists (CA), used for the treatment of patients with arterial hypertension (AH) and coronary heart disea...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
1970-01-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2181 |
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| _version_ | 1839578251142365184 |
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| author | M. V. Leonova |
| author_facet | M. V. Leonova |
| author_sort | M. V. Leonova |
| collection | DOAJ |
| description | The paper reviews the modern evidence on mechanisms of action and clinical effectiveness of two cardiovascular medication classes – angiotensin-converting enzyme (ACE) inhibitors and calcium antagonists (CA), used for the treatment of patients with arterial hypertension (AH) and coronary heart disease (CHD). ACE inhibitors and CA have complementary effects on vascular tone and endothelial function, as well as synergetic action in terms of blood pressure (BP) reduction, pleiotropic effects, organo-protection, and clinical event prevention. Therefore, these mediations can be used as combined cardiovascular therapy. Perindopril and amlodipine, both as monotherapy or combined treatment, have the largest evidence base and potential for clinical practice. |
| format | Article |
| id | doaj-art-defe8045a9bb4ca1a3d3f4f3942ef0fb |
| institution | Matheson Library |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 1970-01-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-defe8045a9bb4ca1a3d3f4f3942ef0fb2025-08-04T12:50:08Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01251970-01-019855621890Clinical pharmacology of the combination of ACE inhibitors and calcium antagonists: benefits of the perindopril arginine and amlodipine combinationM. V. Leonova0Russian State Medical University. MoscowThe paper reviews the modern evidence on mechanisms of action and clinical effectiveness of two cardiovascular medication classes – angiotensin-converting enzyme (ACE) inhibitors and calcium antagonists (CA), used for the treatment of patients with arterial hypertension (AH) and coronary heart disease (CHD). ACE inhibitors and CA have complementary effects on vascular tone and endothelial function, as well as synergetic action in terms of blood pressure (BP) reduction, pleiotropic effects, organo-protection, and clinical event prevention. Therefore, these mediations can be used as combined cardiovascular therapy. Perindopril and amlodipine, both as monotherapy or combined treatment, have the largest evidence base and potential for clinical practice.https://cardiovascular.elpub.ru/jour/article/view/2181renin-angiotensin systemendothelial dysfunctionace inhibitorscalcium antagonistsarterial hypertensioncoronary heart disease |
| spellingShingle | M. V. Leonova Clinical pharmacology of the combination of ACE inhibitors and calcium antagonists: benefits of the perindopril arginine and amlodipine combination Кардиоваскулярная терапия и профилактика renin-angiotensin system endothelial dysfunction ace inhibitors calcium antagonists arterial hypertension coronary heart disease |
| title | Clinical pharmacology of the combination of ACE inhibitors and calcium antagonists: benefits of the perindopril arginine and amlodipine combination |
| title_full | Clinical pharmacology of the combination of ACE inhibitors and calcium antagonists: benefits of the perindopril arginine and amlodipine combination |
| title_fullStr | Clinical pharmacology of the combination of ACE inhibitors and calcium antagonists: benefits of the perindopril arginine and amlodipine combination |
| title_full_unstemmed | Clinical pharmacology of the combination of ACE inhibitors and calcium antagonists: benefits of the perindopril arginine and amlodipine combination |
| title_short | Clinical pharmacology of the combination of ACE inhibitors and calcium antagonists: benefits of the perindopril arginine and amlodipine combination |
| title_sort | clinical pharmacology of the combination of ace inhibitors and calcium antagonists benefits of the perindopril arginine and amlodipine combination |
| topic | renin-angiotensin system endothelial dysfunction ace inhibitors calcium antagonists arterial hypertension coronary heart disease |
| url | https://cardiovascular.elpub.ru/jour/article/view/2181 |
| work_keys_str_mv | AT mvleonova clinicalpharmacologyofthecombinationofaceinhibitorsandcalciumantagonistsbenefitsoftheperindoprilarginineandamlodipinecombination |