Umbilical cord coiling index in predicting neonatal outcomes: a single-center cross-sectional study from Vietnam
Background Abnormal umbilical coiling (AUC) is one of the common occurrences of umbilical cord abnormalities leading to poor neonatal outcomes.Objectives This study aims to investigate the association between antenatal umbilical coiling index (aUCI) and perinatal outcomes as well as the risk factors...
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Taylor & Francis Group
2025-12-01
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| Series: | The Journal of Maternal-Fetal & Neonatal Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/14767058.2025.2517763 |
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| author | Thao Nguyen Nguyen Tran Hong Trung Nguyen Ngoc Thanh Cao Phuc Nhon Nguyen Linh Giang Truong Thi Minh Tam Le Quoc Huy Nguyen Vu |
| author_facet | Thao Nguyen Nguyen Tran Hong Trung Nguyen Ngoc Thanh Cao Phuc Nhon Nguyen Linh Giang Truong Thi Minh Tam Le Quoc Huy Nguyen Vu |
| author_sort | Thao Nguyen Nguyen Tran |
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| description | Background Abnormal umbilical coiling (AUC) is one of the common occurrences of umbilical cord abnormalities leading to poor neonatal outcomes.Objectives This study aims to investigate the association between antenatal umbilical coiling index (aUCI) and perinatal outcomes as well as the risk factors relating to AUC.Methods A cross-sectional study was conducted between June 2022 and June 2024 at Hue University of Medicine and Pharmacy, Vietnam. The study enrolled 337 full-term primigravida with uncomplicated singleton pregnancies who underwent transabdominal ultrasound between 37+0 and 41+0 weeks of gestation for aUCI by color Doppler ultrasound. The aUCI was calculated as the reciprocal of the distance between a pair of coils. The aUCI was classified as hypo-, hyper-, and normocoiled. The patients were monitored until birth delivery, and any adverse antenatal complications were noted.Results The mean aUCI among hypo-, normo-, hypercoiling group were 0.16 ± 0.003, 0.30 ± 0.06, 0.46 ± 0.04. There was a statistically significant different between the resistance index (RI), pulsatility index (PI) of umbilical artery, PI of middle cerebral artery, and the cerebroplacental ratio (CPR) among 3 groups. Overall, the rate of abnormal fetal heart rate tracing, meconium-stained amniotic fluid, cesarean section rate, fetal growth restriction (FGR), and Apgar scores at 5 mins below 7 points was higher in the hypercoiling group (28.2%, 36.6%, 50.7%, 8.5%, 4.2%, respectively) and hypocoiling groups (5.0%, 10.0%, 35.0%, 17.5%, 12.5%, respectively) compared to the normocoiling group (15.0%, 12.4%, 27.9%, 1.8%, 0.9%, respectively), p < 0.05. In general, AUC increased significantly the risk of FGR and Apgar score at 5 mins < 7 points with odds ratio (OR): 7.63 (95% confidence interval (CI): 2.34–23.15) and OR: 8.70 (95%CI: 1.82–41.69). More than 2-fold increased rate of meconium-stained amniotic fluid, cesarean delivery, and birth weight below 2500 grams were also observed. After adjusting for gestational age, gestational hypertension disorders, gestational diabetes mellitus, oligohydramnios/hydramnios were significantly related to the development of AUC with OR: 4.99; 7.92, 4.96; 4.56, respectively.Conclusion Both abnormal umbilical coiling in the form of either hypocoiling or hypercoiling are associated with adverse pregnancy outcomes. Thus, the antenatal umbilical coiling index ought to be detected during routine antenatal care. |
| format | Article |
| id | doaj-art-def3ee80cce04bb49f806f033fe9ffb9 |
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| issn | 1476-7058 1476-4954 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | The Journal of Maternal-Fetal & Neonatal Medicine |
| spelling | doaj-art-def3ee80cce04bb49f806f033fe9ffb92025-07-07T01:39:34ZengTaylor & Francis GroupThe Journal of Maternal-Fetal & Neonatal Medicine1476-70581476-49542025-12-0138110.1080/14767058.2025.2517763Umbilical cord coiling index in predicting neonatal outcomes: a single-center cross-sectional study from VietnamThao Nguyen Nguyen Tran0Hong Trung Nguyen1Ngoc Thanh Cao2Phuc Nhon Nguyen3Linh Giang Truong Thi4Minh Tam Le5Quoc Huy Nguyen Vu6Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue City, VietnamObstetrics and Gynecology Center, Hue Central Hospital, Hue City, VietnamDepartment of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue City, VietnamDepartment of Pregnancy Pathology, Tu Du Hospital, Ho Chi Minh City, VietnamDepartment of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue City, VietnamDepartment of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue City, VietnamDepartment of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue City, VietnamBackground Abnormal umbilical coiling (AUC) is one of the common occurrences of umbilical cord abnormalities leading to poor neonatal outcomes.Objectives This study aims to investigate the association between antenatal umbilical coiling index (aUCI) and perinatal outcomes as well as the risk factors relating to AUC.Methods A cross-sectional study was conducted between June 2022 and June 2024 at Hue University of Medicine and Pharmacy, Vietnam. The study enrolled 337 full-term primigravida with uncomplicated singleton pregnancies who underwent transabdominal ultrasound between 37+0 and 41+0 weeks of gestation for aUCI by color Doppler ultrasound. The aUCI was calculated as the reciprocal of the distance between a pair of coils. The aUCI was classified as hypo-, hyper-, and normocoiled. The patients were monitored until birth delivery, and any adverse antenatal complications were noted.Results The mean aUCI among hypo-, normo-, hypercoiling group were 0.16 ± 0.003, 0.30 ± 0.06, 0.46 ± 0.04. There was a statistically significant different between the resistance index (RI), pulsatility index (PI) of umbilical artery, PI of middle cerebral artery, and the cerebroplacental ratio (CPR) among 3 groups. Overall, the rate of abnormal fetal heart rate tracing, meconium-stained amniotic fluid, cesarean section rate, fetal growth restriction (FGR), and Apgar scores at 5 mins below 7 points was higher in the hypercoiling group (28.2%, 36.6%, 50.7%, 8.5%, 4.2%, respectively) and hypocoiling groups (5.0%, 10.0%, 35.0%, 17.5%, 12.5%, respectively) compared to the normocoiling group (15.0%, 12.4%, 27.9%, 1.8%, 0.9%, respectively), p < 0.05. In general, AUC increased significantly the risk of FGR and Apgar score at 5 mins < 7 points with odds ratio (OR): 7.63 (95% confidence interval (CI): 2.34–23.15) and OR: 8.70 (95%CI: 1.82–41.69). More than 2-fold increased rate of meconium-stained amniotic fluid, cesarean delivery, and birth weight below 2500 grams were also observed. After adjusting for gestational age, gestational hypertension disorders, gestational diabetes mellitus, oligohydramnios/hydramnios were significantly related to the development of AUC with OR: 4.99; 7.92, 4.96; 4.56, respectively.Conclusion Both abnormal umbilical coiling in the form of either hypocoiling or hypercoiling are associated with adverse pregnancy outcomes. Thus, the antenatal umbilical coiling index ought to be detected during routine antenatal care.https://www.tandfonline.com/doi/10.1080/14767058.2025.2517763Antenatal careDoppler ultrasoundhigh-risk pregnanciesumbilical coiling indexVietnam |
| spellingShingle | Thao Nguyen Nguyen Tran Hong Trung Nguyen Ngoc Thanh Cao Phuc Nhon Nguyen Linh Giang Truong Thi Minh Tam Le Quoc Huy Nguyen Vu Umbilical cord coiling index in predicting neonatal outcomes: a single-center cross-sectional study from Vietnam The Journal of Maternal-Fetal & Neonatal Medicine Antenatal care Doppler ultrasound high-risk pregnancies umbilical coiling index Vietnam |
| title | Umbilical cord coiling index in predicting neonatal outcomes: a single-center cross-sectional study from Vietnam |
| title_full | Umbilical cord coiling index in predicting neonatal outcomes: a single-center cross-sectional study from Vietnam |
| title_fullStr | Umbilical cord coiling index in predicting neonatal outcomes: a single-center cross-sectional study from Vietnam |
| title_full_unstemmed | Umbilical cord coiling index in predicting neonatal outcomes: a single-center cross-sectional study from Vietnam |
| title_short | Umbilical cord coiling index in predicting neonatal outcomes: a single-center cross-sectional study from Vietnam |
| title_sort | umbilical cord coiling index in predicting neonatal outcomes a single center cross sectional study from vietnam |
| topic | Antenatal care Doppler ultrasound high-risk pregnancies umbilical coiling index Vietnam |
| url | https://www.tandfonline.com/doi/10.1080/14767058.2025.2517763 |
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