18S ribosomal RNA methyltransferase METTL5-mediated CDX2 translation regulates porcine early embryo development

18S ribosomal RNA methyltransferase METTL5-mediated CDX2 translation regulates porcine early embryo development

N6-methyladenosine (m6A) plays a key role in mammalian early embryonic development and cell lineage differentiation. However, the role and mechanisms of 18S ribosomal RNA (rRNA) m6A methyltransferase METTL5 in early embryonic development remain unclear. Here, we found that 18S rRNA m6A methyltransfe...

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Main Authors: Tengteng Xu, Mengya Zhang, Qiuchen Liu, Xin Wang, Pengfei Luo, Tong Liu, Yelian Yan, Naru Zhou, Yangyang Ma, Tong Yu, Yunsheng Li, Zubing Cao, Yunhai Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-08-01
Series:Journal of Integrative Agriculture
Subjects:
pig
rRNA m6A
CDX2
mRNA translation
lineage segregation
Online Access:http://www.sciencedirect.com/science/article/pii/S2095311923003556
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