Growth hormone combined with estrogen improves intrauterine adhesion fibrosis by downregulating endometrial microbial citraconic acid to target β-catenin protein

Growth hormone combined with estrogen improves intrauterine adhesion fibrosis by downregulating endometrial microbial citraconic acid to target β-catenin protein

ABSTRACT Intrauterine adhesions (IUAs) are a major cause of secondary infertility. This study aimed to investigate the therapeutic effects and mechanisms of combined recombinant rat growth hormone (rrGH) and estrogen therapy on endometrial fibrosis in IUA rats. Our findings revealed that IUA rats ex...

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Bibliographic Details
Main Authors: Yuhua Zeng, Yanfei Yang, Fei Zeng, Qing Feng
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mSystems
Subjects:
intrauterine adhesions
growth hormone
estrogen
endometrial microbiota
citraconic acid
β-catenin pathway
Online Access:https://journals.asm.org/doi/10.1128/msystems.01692-24
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