CLINICAL IMPORTANCE OF DETERMINATION OF HLA-DRB1 LOCUS GENES IN RHEUMATOID ARTHRITIS

CLINICAL IMPORTANCE OF DETERMINATION OF HLA-DRB1 LOCUS GENES IN RHEUMATOID ARTHRITIS

Rheumatoid arthritis (RA) is a most common autoimmune inflammatory arthritis in adults. Serological marker of RA are rheumatoid factor (RF) and antibodies to cyclic citrullinated peptide (ACCP). The main genetic factor that determine predisposition to RA is HLA-DRB1 alleles. The HLA-DRB1 locus allel...

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Bibliographic Details
Main Authors: V. Guseva, S. Lapin, V. Myachikova, A. Maslyanski, A. Chuchlovin, N. Ivanova, O. Tkachenko, T. Blinova, A. Totolian
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2019-05-01
Series:Медицинская иммунология
Subjects:
rheumatoid arthritis
antibodies to cyclic citrullinated peptide
smoking
hla-drb1
Online Access:https://www.mimmun.ru/mimmun/article/view/1500
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