Role of Nitric Oxide in Neuronal Damages in Critical Conditions
The presented review of literature covers the current notions of the role of nitric oxide and its metabolism in the development of encephalopathies in critically ill patients. The mechanisms of nitric oxide involvement in neurotoxicity, neuronal induction of apoptosis, and the types of nitric oxide...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2009-10-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/542 |
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| author | A. V. Kiseleva Yu. A. Churlyaev Ye. V. Grigoryev |
| author_facet | A. V. Kiseleva Yu. A. Churlyaev Ye. V. Grigoryev |
| author_sort | A. V. Kiseleva |
| collection | DOAJ |
| description | The presented review of literature covers the current notions of the role of nitric oxide and its metabolism in the development of encephalopathies in critically ill patients. The mechanisms of nitric oxide involvement in neurotoxicity, neuronal induction of apoptosis, and the types of nitric oxide involvement in the development of brain ischemia, focal cerebral damage in severe brain injury are described. A concise review of the experimentally founded therapy options aimed at correcting nitric oxide-induced neuronal damage (modulation of nitric oxide synthesis, antioxidants) is given. Key words: brain ischemia, brain traumatic injuries, nitric oxide synthase variants, neurotoxicity, apoptosis, correction modes. |
| format | Article |
| id | doaj-art-dd16c6d891a54c49bd125c6ff7e51e09 |
| institution | Matheson Library |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2009-10-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-dd16c6d891a54c49bd125c6ff7e51e092025-08-04T10:40:39ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102009-10-015510.15360/1813-9779-2009-5-80542Role of Nitric Oxide in Neuronal Damages in Critical ConditionsA. V. KiselevaYu. A. ChurlyaevYe. V. GrigoryevThe presented review of literature covers the current notions of the role of nitric oxide and its metabolism in the development of encephalopathies in critically ill patients. The mechanisms of nitric oxide involvement in neurotoxicity, neuronal induction of apoptosis, and the types of nitric oxide involvement in the development of brain ischemia, focal cerebral damage in severe brain injury are described. A concise review of the experimentally founded therapy options aimed at correcting nitric oxide-induced neuronal damage (modulation of nitric oxide synthesis, antioxidants) is given. Key words: brain ischemia, brain traumatic injuries, nitric oxide synthase variants, neurotoxicity, apoptosis, correction modes.https://www.reanimatology.com/rmt/article/view/542 |
| spellingShingle | A. V. Kiseleva Yu. A. Churlyaev Ye. V. Grigoryev Role of Nitric Oxide in Neuronal Damages in Critical Conditions Общая реаниматология |
| title | Role of Nitric Oxide in Neuronal Damages in Critical Conditions |
| title_full | Role of Nitric Oxide in Neuronal Damages in Critical Conditions |
| title_fullStr | Role of Nitric Oxide in Neuronal Damages in Critical Conditions |
| title_full_unstemmed | Role of Nitric Oxide in Neuronal Damages in Critical Conditions |
| title_short | Role of Nitric Oxide in Neuronal Damages in Critical Conditions |
| title_sort | role of nitric oxide in neuronal damages in critical conditions |
| url | https://www.reanimatology.com/rmt/article/view/542 |
| work_keys_str_mv | AT avkiseleva roleofnitricoxideinneuronaldamagesincriticalconditions AT yuachurlyaev roleofnitricoxideinneuronaldamagesincriticalconditions AT yevgrigoryev roleofnitricoxideinneuronaldamagesincriticalconditions |