Role of Nitric Oxide in Neuronal Damages in Critical Conditions
The presented review of literature covers the current notions of the role of nitric oxide and its metabolism in the development of encephalopathies in critically ill patients. The mechanisms of nitric oxide involvement in neurotoxicity, neuronal induction of apoptosis, and the types of nitric oxide...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2009-10-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/542 |
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| Summary: | The presented review of literature covers the current notions of the role of nitric oxide and its metabolism in the development of encephalopathies in critically ill patients. The mechanisms of nitric oxide involvement in neurotoxicity, neuronal induction of apoptosis, and the types of nitric oxide involvement in the development of brain ischemia, focal cerebral damage in severe brain injury are described. A concise review of the experimentally founded therapy options aimed at correcting nitric oxide-induced neuronal damage (modulation of nitric oxide synthesis, antioxidants) is given. Key words: brain ischemia, brain traumatic injuries, nitric oxide synthase variants, neurotoxicity, apoptosis, correction modes. |
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| ISSN: | 1813-9779 2411-7110 |