THE FIRST RUSSIAN EXPERIENCE OF ABO-INCOMPATIBLE KIDNEY TRANSPLANTATION WITH ANTIGEN-SPECIFIC IMMUNOADSORPTION
We report the first Russian experience of successful ABO-incompatible kidney transplantation using anti-CD20 + IA + IvIg pretransplant conditioning protocol and tacrolimus + MMF + steroids as maintenance immunosuppression. IA procedures were performed on reusable columns ABO-Adsopak® (POCARD Ltd. Mo...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2011-12-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/387 |
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| author | Y. G. Moysyuk A. I. Sushkov N. V. Pulkova V. Y. Abramov A. G. Kupriyanova B. N. Morozov A. K. Porunova N. P. Obraztsova I. Y. Adamova S. V. Gautier |
| author_facet | Y. G. Moysyuk A. I. Sushkov N. V. Pulkova V. Y. Abramov A. G. Kupriyanova B. N. Morozov A. K. Porunova N. P. Obraztsova I. Y. Adamova S. V. Gautier |
| author_sort | Y. G. Moysyuk |
| collection | DOAJ |
| description | We report the first Russian experience of successful ABO-incompatible kidney transplantation using anti-CD20 + IA + IvIg pretransplant conditioning protocol and tacrolimus + MMF + steroids as maintenance immunosuppression. IA procedures were performed on reusable columns ABO-Adsopak® (POCARD Ltd. Moscow, Russia). IA treatments following the administration of rituximab efficiently lowered the immunoglobulin M (IgM) and G (IgG) anti-A/B antibodies titers in all patients. The transplantation could be performed in all cases and the kidneys showed primary function. Unfortunately, the biopsy-proven clinical antibody-mediated rejection (AMR) occurred in one case. Episo- de of AMR was successfully reversed. On 6, 4 and 2 months follow-up, serum creatinine levels were 117, 127 and 87 μmol/l, respectively. We consider ABO-incompatible transplantation as a safe and promising procedure in particu- lar cases for those patients having related but ABO-incompatible donors. Given the shortage of donor organs ABO- incompatible living donor kidney transplantation may become a treatment of choice for many patients. |
| format | Article |
| id | doaj-art-dbdc0d637e8448e9a183e58e307226e3 |
| institution | Matheson Library |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2011-12-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-dbdc0d637e8448e9a183e58e307226e32025-08-04T14:02:05ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912011-12-0113461810.15825/1995-1191-2011-4-6-18330THE FIRST RUSSIAN EXPERIENCE OF ABO-INCOMPATIBLE KIDNEY TRANSPLANTATION WITH ANTIGEN-SPECIFIC IMMUNOADSORPTIONY. G. Moysyuk0A. I. Sushkov1N. V. Pulkova2V. Y. Abramov3A. G. Kupriyanova4B. N. Morozov5A. K. Porunova6N. P. Obraztsova7I. Y. Adamova8S. V. Gautier9Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowPOCARD Ltd., MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowWe report the first Russian experience of successful ABO-incompatible kidney transplantation using anti-CD20 + IA + IvIg pretransplant conditioning protocol and tacrolimus + MMF + steroids as maintenance immunosuppression. IA procedures were performed on reusable columns ABO-Adsopak® (POCARD Ltd. Moscow, Russia). IA treatments following the administration of rituximab efficiently lowered the immunoglobulin M (IgM) and G (IgG) anti-A/B antibodies titers in all patients. The transplantation could be performed in all cases and the kidneys showed primary function. Unfortunately, the biopsy-proven clinical antibody-mediated rejection (AMR) occurred in one case. Episo- de of AMR was successfully reversed. On 6, 4 and 2 months follow-up, serum creatinine levels were 117, 127 and 87 μmol/l, respectively. We consider ABO-incompatible transplantation as a safe and promising procedure in particu- lar cases for those patients having related but ABO-incompatible donors. Given the shortage of donor organs ABO- incompatible living donor kidney transplantation may become a treatment of choice for many patients.https://journal.transpl.ru/vtio/article/view/387kidney transplantationblood group incompatibilityimmunoadsorptionantibody-mediated rejection. |
| spellingShingle | Y. G. Moysyuk A. I. Sushkov N. V. Pulkova V. Y. Abramov A. G. Kupriyanova B. N. Morozov A. K. Porunova N. P. Obraztsova I. Y. Adamova S. V. Gautier THE FIRST RUSSIAN EXPERIENCE OF ABO-INCOMPATIBLE KIDNEY TRANSPLANTATION WITH ANTIGEN-SPECIFIC IMMUNOADSORPTION Вестник трансплантологии и искусственных органов kidney transplantation blood group incompatibility immunoadsorption antibody-mediated rejection. |
| title | THE FIRST RUSSIAN EXPERIENCE OF ABO-INCOMPATIBLE KIDNEY TRANSPLANTATION WITH ANTIGEN-SPECIFIC IMMUNOADSORPTION |
| title_full | THE FIRST RUSSIAN EXPERIENCE OF ABO-INCOMPATIBLE KIDNEY TRANSPLANTATION WITH ANTIGEN-SPECIFIC IMMUNOADSORPTION |
| title_fullStr | THE FIRST RUSSIAN EXPERIENCE OF ABO-INCOMPATIBLE KIDNEY TRANSPLANTATION WITH ANTIGEN-SPECIFIC IMMUNOADSORPTION |
| title_full_unstemmed | THE FIRST RUSSIAN EXPERIENCE OF ABO-INCOMPATIBLE KIDNEY TRANSPLANTATION WITH ANTIGEN-SPECIFIC IMMUNOADSORPTION |
| title_short | THE FIRST RUSSIAN EXPERIENCE OF ABO-INCOMPATIBLE KIDNEY TRANSPLANTATION WITH ANTIGEN-SPECIFIC IMMUNOADSORPTION |
| title_sort | first russian experience of abo incompatible kidney transplantation with antigen specific immunoadsorption |
| topic | kidney transplantation blood group incompatibility immunoadsorption antibody-mediated rejection. |
| url | https://journal.transpl.ru/vtio/article/view/387 |
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