Activation of YAP/TAZ by gut microbiota via Wnt/β-catenin signaling in cancer development
This review examines the role of gut microbiota in the activation of the Wnt/β-catenin signaling pathway and its impact on cancer progression via YAP/TAZ activation. Yes-associated protein, YAP, is a transcriptional coactivator involved in regulating gene expression and cell proliferation...
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Academia.edu Journals
2025-04-01
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| Series: | Academia Molecular Biology and Genomics |
| Online Access: | https://www.academia.edu/128553729/Activation_of_YAP_TAZ_by_Gut_Microbiota_via_Wnt_%CE%B2_Catenin_Signaling_in_Cancer_Development |
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| _version_ | 1839628601761202176 |
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| author | Shahin Javanmard Kayhan Ertürk |
| author_facet | Shahin Javanmard Kayhan Ertürk |
| author_sort | Shahin Javanmard |
| collection | DOAJ |
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This review examines the role of gut microbiota in the activation of the Wnt/β-catenin signaling pathway and its impact on cancer progression via YAP/TAZ activation. Yes-associated protein, YAP, is a transcriptional coactivator involved in regulating gene expression and cell proliferation by interacting with TEA domain (TEAD) transcription factor in the Hippo signaling pathway. The Wnt/β-catenin pathway is an evolutionarily conserved pathway that is important for development and tissue homeostasis but was described as driving oncogenic processes through YAP/TAZ activity. In this regard, gut microbiota metabolites drove tumor development by activating the Wnt/β-catenin pathway onto YAP/TAZ activation with increased evidence. This review discusses recent studies on the modulation of gut microbiota and its effect on Wnt/β-catenin signaling and further pursues the effects of cancer treatment and prevention. |
| format | Article |
| id | doaj-art-dbcd192ef1d84ca08e5bcb8e12e95481 |
| institution | Matheson Library |
| issn | 3064-9765 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Academia.edu Journals |
| record_format | Article |
| series | Academia Molecular Biology and Genomics |
| spelling | doaj-art-dbcd192ef1d84ca08e5bcb8e12e954812025-07-15T16:09:41ZengAcademia.edu JournalsAcademia Molecular Biology and Genomics3064-97652025-04-012210.20935/AcadMolBioGen7642Activation of YAP/TAZ by gut microbiota via Wnt/β-catenin signaling in cancer developmentShahin Javanmard0Kayhan Ertürk1Faculty of Medicine, Halic University, 5. Levent Mahallesi, Eyüpsultan, 34060 İstanbul, Türkiye.Faculty of Medicine, University of Health Sciences, Üsküdar, 34668 İstanbul, Türkiye. This review examines the role of gut microbiota in the activation of the Wnt/β-catenin signaling pathway and its impact on cancer progression via YAP/TAZ activation. Yes-associated protein, YAP, is a transcriptional coactivator involved in regulating gene expression and cell proliferation by interacting with TEA domain (TEAD) transcription factor in the Hippo signaling pathway. The Wnt/β-catenin pathway is an evolutionarily conserved pathway that is important for development and tissue homeostasis but was described as driving oncogenic processes through YAP/TAZ activity. In this regard, gut microbiota metabolites drove tumor development by activating the Wnt/β-catenin pathway onto YAP/TAZ activation with increased evidence. This review discusses recent studies on the modulation of gut microbiota and its effect on Wnt/β-catenin signaling and further pursues the effects of cancer treatment and prevention.https://www.academia.edu/128553729/Activation_of_YAP_TAZ_by_Gut_Microbiota_via_Wnt_%CE%B2_Catenin_Signaling_in_Cancer_Development |
| spellingShingle | Shahin Javanmard Kayhan Ertürk Activation of YAP/TAZ by gut microbiota via Wnt/β-catenin signaling in cancer development Academia Molecular Biology and Genomics |
| title | Activation of YAP/TAZ by gut microbiota via Wnt/β-catenin signaling in cancer development |
| title_full | Activation of YAP/TAZ by gut microbiota via Wnt/β-catenin signaling in cancer development |
| title_fullStr | Activation of YAP/TAZ by gut microbiota via Wnt/β-catenin signaling in cancer development |
| title_full_unstemmed | Activation of YAP/TAZ by gut microbiota via Wnt/β-catenin signaling in cancer development |
| title_short | Activation of YAP/TAZ by gut microbiota via Wnt/β-catenin signaling in cancer development |
| title_sort | activation of yap taz by gut microbiota via wnt β catenin signaling in cancer development |
| url | https://www.academia.edu/128553729/Activation_of_YAP_TAZ_by_Gut_Microbiota_via_Wnt_%CE%B2_Catenin_Signaling_in_Cancer_Development |
| work_keys_str_mv | AT shahinjavanmard activationofyaptazbygutmicrobiotaviawntbcateninsignalingincancerdevelopment AT kayhanerturk activationofyaptazbygutmicrobiotaviawntbcateninsignalingincancerdevelopment |