The phenomenon of RNA interference in oncology: advances, problems and perspectives
Review describes the phenomenon of RNA interference – the recently discovered biological mechanism of the negative regulation of gene expression. The mechanism is based on the block of the translation and/or degradation of messenger RNA under short non-coding RNA, among them: microRNA and small inte...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2016-09-01
|
| Series: | Успехи молекулярной онкологии |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/66 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839573483108958208 |
|---|---|
| author | O. E. Andreeva M. A. Krasil’nikov |
| author_facet | O. E. Andreeva M. A. Krasil’nikov |
| author_sort | O. E. Andreeva |
| collection | DOAJ |
| description | Review describes the phenomenon of RNA interference – the recently discovered biological mechanism of the negative regulation of gene expression. The mechanism is based on the block of the translation and/or degradation of messenger RNA under short non-coding RNA, among them: microRNA and small interfering RNA. The paper reviews the molecular processes of the formation of small RNA, the mechanism of their action and the feasibility of small RNA implementation in the anti-tumor therapy. Specially, we analyze the approaches to in vivo delivery of small RNA, in particular – the liposome and exosome constructs, and perspectives of the involvement of such constructs in the cancer treatment. |
| format | Article |
| id | doaj-art-dba27a9ff4cf4c5e9d857ad78f127f2c |
| institution | Matheson Library |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2016-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-dba27a9ff4cf4c5e9d857ad78f127f2c2025-08-04T14:04:34ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872016-09-013381510.17650/2313-805X-2016-3-3-08-1562The phenomenon of RNA interference in oncology: advances, problems and perspectivesO. E. Andreeva0M. A. Krasil’nikov1Research Institute of Carcinogenesis, N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, RussiaResearch Institute of Carcinogenesis, N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, RussiaReview describes the phenomenon of RNA interference – the recently discovered biological mechanism of the negative regulation of gene expression. The mechanism is based on the block of the translation and/or degradation of messenger RNA under short non-coding RNA, among them: microRNA and small interfering RNA. The paper reviews the molecular processes of the formation of small RNA, the mechanism of their action and the feasibility of small RNA implementation in the anti-tumor therapy. Specially, we analyze the approaches to in vivo delivery of small RNA, in particular – the liposome and exosome constructs, and perspectives of the involvement of such constructs in the cancer treatment.https://umo.abvpress.ru/jour/article/view/66rna interferencemalignant tumormicrornasmall interfering rnarna deliveryliposomeexosome |
| spellingShingle | O. E. Andreeva M. A. Krasil’nikov The phenomenon of RNA interference in oncology: advances, problems and perspectives Успехи молекулярной онкологии rna interference malignant tumor microrna small interfering rna rna delivery liposome exosome |
| title | The phenomenon of RNA interference in oncology: advances, problems and perspectives |
| title_full | The phenomenon of RNA interference in oncology: advances, problems and perspectives |
| title_fullStr | The phenomenon of RNA interference in oncology: advances, problems and perspectives |
| title_full_unstemmed | The phenomenon of RNA interference in oncology: advances, problems and perspectives |
| title_short | The phenomenon of RNA interference in oncology: advances, problems and perspectives |
| title_sort | phenomenon of rna interference in oncology advances problems and perspectives |
| topic | rna interference malignant tumor microrna small interfering rna rna delivery liposome exosome |
| url | https://umo.abvpress.ru/jour/article/view/66 |
| work_keys_str_mv | AT oeandreeva thephenomenonofrnainterferenceinoncologyadvancesproblemsandperspectives AT makrasilnikov thephenomenonofrnainterferenceinoncologyadvancesproblemsandperspectives AT oeandreeva phenomenonofrnainterferenceinoncologyadvancesproblemsandperspectives AT makrasilnikov phenomenonofrnainterferenceinoncologyadvancesproblemsandperspectives |