Efficiency of ADOPTIVE immunotherapy for melanoma: a case REPORT
A lot of research is focused on finding better treatment options for cancer. Along with radical treatment, cancer immunotherapy has proved to be useful for a growing number of cancer patients. We report a case of stage IIIB melanoma in a 53-year woman who received adoptive immunotherapy with cytokin...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-11-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/411 |
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| author | E. V. Abakushina I. A. Pasova Yu. V. Marizina D. V. Kudryavtsev G. T. Kudryavtseva E. S. Fomina |
| author_facet | E. V. Abakushina I. A. Pasova Yu. V. Marizina D. V. Kudryavtsev G. T. Kudryavtseva E. S. Fomina |
| author_sort | E. V. Abakushina |
| collection | DOAJ |
| description | A lot of research is focused on finding better treatment options for cancer. Along with radical treatment, cancer immunotherapy has proved to be useful for a growing number of cancer patients. We report a case of stage IIIB melanoma in a 53-year woman who received adoptive immunotherapy with cytokine-induced killer (CIK) cells. For activation, mononuclear cells were collected from the patient’s peripheral blood and cultivated in X-vivo20 medium containing IL-2 (250 U/ml) and IL-15 (50 ng/ml) for 10-14 days. From January 2015 to May 2016, a total of 39 CIK cell infusions were administered intradermally to 2-4 points in the paravertebral area, every 1–2 weeks. Flow cytometric analysis of peripheral blood lymphocytes in 3 months after starting CIK cell immunotherapy showed a decrease in the number of NK-cells from 18 % to 12 % and CD314 + NK-cells from 16% to 6%. The levels of CD38+, CD38+Т, HLA-DR+ and HLA-DR+Т lymphocytes increased from 53 %, 24 %, 21 %, 9 % and 19 % to 66 %, 51 %, 28 %, 20 % and 29 %, respectively. There was evidence of reactive changes in lymph nodes and stable disease. Metastases on the left shoulder tended to decrease, and they completely disappeared 9 months after tarting adoptive immunotherapy. Partial regression of metastasis on the right shoulder was observed 11 month after staring adoptive immunotherapy. Adoptive immunotherapy demonstrated the increased disease-free survival for the patient with melanoma. In conclusion, CIK immunotherapy may be an effective treatment method for metastatic melanoma. |
| format | Article |
| id | doaj-art-dba0b00f016e46d2bee2e36aa75b2e1a |
| institution | Matheson Library |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-11-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-dba0b00f016e46d2bee2e36aa75b2e1a2025-08-04T10:33:37ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-11-01155899410.21294/1814-4861-2016-15-5-3-7380Efficiency of ADOPTIVE immunotherapy for melanoma: a case REPORTE. V. Abakushina0I. A. Pasova1Yu. V. Marizina2D. V. Kudryavtsev3G. T. Kudryavtseva4E. S. Fomina5A. Tsyb Medical Radiological Research Centre, Russia, Obninsk 4, Koroleva Street, 249036- Obninsk, Kaluga Region, RussiaA. Tsyb Medical Radiological Research Centre, Russia, Obninsk 4, Koroleva Street, 249036- Obninsk, Kaluga Region, RussiaA. Tsyb Medical Radiological Research Centre, Russia, Obninsk 4, Koroleva Street, 249036- Obninsk, Kaluga Region, RussiaA. Tsyb Medical Radiological Research Centre, Russia, Obninsk 4, Koroleva Street, 249036- Obninsk, Kaluga Region, RussiaA. Tsyb Medical Radiological Research Centre, Russia, Obninsk 4, Koroleva Street, 249036- Obninsk, Kaluga Region, RussiaA. Tsyb Medical Radiological Research Centre, Russia, Obninsk 4, Koroleva Street, 249036- Obninsk, Kaluga Region, RussiaA lot of research is focused on finding better treatment options for cancer. Along with radical treatment, cancer immunotherapy has proved to be useful for a growing number of cancer patients. We report a case of stage IIIB melanoma in a 53-year woman who received adoptive immunotherapy with cytokine-induced killer (CIK) cells. For activation, mononuclear cells were collected from the patient’s peripheral blood and cultivated in X-vivo20 medium containing IL-2 (250 U/ml) and IL-15 (50 ng/ml) for 10-14 days. From January 2015 to May 2016, a total of 39 CIK cell infusions were administered intradermally to 2-4 points in the paravertebral area, every 1–2 weeks. Flow cytometric analysis of peripheral blood lymphocytes in 3 months after starting CIK cell immunotherapy showed a decrease in the number of NK-cells from 18 % to 12 % and CD314 + NK-cells from 16% to 6%. The levels of CD38+, CD38+Т, HLA-DR+ and HLA-DR+Т lymphocytes increased from 53 %, 24 %, 21 %, 9 % and 19 % to 66 %, 51 %, 28 %, 20 % and 29 %, respectively. There was evidence of reactive changes in lymph nodes and stable disease. Metastases on the left shoulder tended to decrease, and they completely disappeared 9 months after tarting adoptive immunotherapy. Partial regression of metastasis on the right shoulder was observed 11 month after staring adoptive immunotherapy. Adoptive immunotherapy demonstrated the increased disease-free survival for the patient with melanoma. In conclusion, CIK immunotherapy may be an effective treatment method for metastatic melanoma.https://www.siboncoj.ru/jour/article/view/411melanomaadoptive immunotherapycytokine-induced killer cellsmarkers of lymphocyte activationadoptive immunotherapy effectiveness |
| spellingShingle | E. V. Abakushina I. A. Pasova Yu. V. Marizina D. V. Kudryavtsev G. T. Kudryavtseva E. S. Fomina Efficiency of ADOPTIVE immunotherapy for melanoma: a case REPORT Сибирский онкологический журнал melanoma adoptive immunotherapy cytokine-induced killer cells markers of lymphocyte activation adoptive immunotherapy effectiveness |
| title | Efficiency of ADOPTIVE immunotherapy for melanoma: a case REPORT |
| title_full | Efficiency of ADOPTIVE immunotherapy for melanoma: a case REPORT |
| title_fullStr | Efficiency of ADOPTIVE immunotherapy for melanoma: a case REPORT |
| title_full_unstemmed | Efficiency of ADOPTIVE immunotherapy for melanoma: a case REPORT |
| title_short | Efficiency of ADOPTIVE immunotherapy for melanoma: a case REPORT |
| title_sort | efficiency of adoptive immunotherapy for melanoma a case report |
| topic | melanoma adoptive immunotherapy cytokine-induced killer cells markers of lymphocyte activation adoptive immunotherapy effectiveness |
| url | https://www.siboncoj.ru/jour/article/view/411 |
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