Sigh generation in preBötzinger complex
We explored neural mechanisms underlying sighing in mice. Photostimulation of parafacial (pF) neuromedin B (NMB) or gastrin-releasing peptide (GRP), or preBötzinger Complex (preBötC) NMBR or GRPR neurons elicited ectopic sighs with latency inversely related to time from preceding endogenous sigh. Of...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2025-06-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/100192 |
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| author | Yan Cui Evgeny Bondarenko Carolina Thörn Perez Delia N Chiu Jack L Feldman |
| author_facet | Yan Cui Evgeny Bondarenko Carolina Thörn Perez Delia N Chiu Jack L Feldman |
| author_sort | Yan Cui |
| collection | DOAJ |
| description | We explored neural mechanisms underlying sighing in mice. Photostimulation of parafacial (pF) neuromedin B (NMB) or gastrin-releasing peptide (GRP), or preBötzinger Complex (preBötC) NMBR or GRPR neurons elicited ectopic sighs with latency inversely related to time from preceding endogenous sigh. Of particular note, ectopic sighs could be produced without involvement of these peptides or their receptors in preBötC. Moreover, chemogenetic or optogenetic activation of preBötC SST neurons induced sighing, even in the presence of NMBR and/or GRPR antagonists. We propose that an increase in the excitability of preBötC NMBR or GRPR neurons not requiring activation of their peptide receptors activates partially overlapping pathways to generate sighs, and that preBötC SST neurons are a downstream element in the sigh generation circuit that converts normal breaths into sighs. |
| format | Article |
| id | doaj-art-db60b26f7c15442a96645fcd8cadb98e |
| institution | Matheson Library |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-db60b26f7c15442a96645fcd8cadb98e2025-06-24T14:18:19ZengeLife Sciences Publications LtdeLife2050-084X2025-06-011310.7554/eLife.100192Sigh generation in preBötzinger complexYan Cui0https://orcid.org/0000-0003-1336-1342Evgeny Bondarenko1https://orcid.org/0000-0003-0631-8936Carolina Thörn Perez2https://orcid.org/0000-0002-3480-8599Delia N Chiu3https://orcid.org/0000-0002-7343-7962Jack L Feldman4https://orcid.org/0000-0003-3692-9412Department of Physiology, Chengdu Medical College, Chengdu, China; Department of Neurobiology, DGSOM, UCLA, Los Angeles, United StatesDepartment of Neurobiology, DGSOM, UCLA, Los Angeles, United StatesDepartment of Neurobiology, DGSOM, UCLA, Los Angeles, United States; Gene Expression Laboratory, Salk Institute for Biological studies, La Jolla, United StatesDepartment of Neurobiology, DGSOM, UCLA, Los Angeles, United States; Synaptic Physiology and Plasticity Group, European Neuroscience Institute Göttingen - A Joint Initiative of the University Medical Center Göttingen and the Max-Planck Society, Göttingen, GermanyDepartment of Neurobiology, DGSOM, UCLA, Los Angeles, United StatesWe explored neural mechanisms underlying sighing in mice. Photostimulation of parafacial (pF) neuromedin B (NMB) or gastrin-releasing peptide (GRP), or preBötzinger Complex (preBötC) NMBR or GRPR neurons elicited ectopic sighs with latency inversely related to time from preceding endogenous sigh. Of particular note, ectopic sighs could be produced without involvement of these peptides or their receptors in preBötC. Moreover, chemogenetic or optogenetic activation of preBötC SST neurons induced sighing, even in the presence of NMBR and/or GRPR antagonists. We propose that an increase in the excitability of preBötC NMBR or GRPR neurons not requiring activation of their peptide receptors activates partially overlapping pathways to generate sighs, and that preBötC SST neurons are a downstream element in the sigh generation circuit that converts normal breaths into sighs.https://elifesciences.org/articles/100192prebötzingersighCPGbreathing |
| spellingShingle | Yan Cui Evgeny Bondarenko Carolina Thörn Perez Delia N Chiu Jack L Feldman Sigh generation in preBötzinger complex eLife prebötzinger sigh CPG breathing |
| title | Sigh generation in preBötzinger complex |
| title_full | Sigh generation in preBötzinger complex |
| title_fullStr | Sigh generation in preBötzinger complex |
| title_full_unstemmed | Sigh generation in preBötzinger complex |
| title_short | Sigh generation in preBötzinger complex |
| title_sort | sigh generation in prebotzinger complex |
| topic | prebötzinger sigh CPG breathing |
| url | https://elifesciences.org/articles/100192 |
| work_keys_str_mv | AT yancui sighgenerationinprebotzingercomplex AT evgenybondarenko sighgenerationinprebotzingercomplex AT carolinathornperez sighgenerationinprebotzingercomplex AT delianchiu sighgenerationinprebotzingercomplex AT jacklfeldman sighgenerationinprebotzingercomplex |