Carbapenem resistance gene blaNDM-1 in Escherichia coli, Serratia marcescens and Klebsiella michiganensis strains from a pediatric patient
Carbapenem resistance has a widespread globally. In this study, three bacterial strains including Escherichia coli (SXY-EC), Serratia marcescens (SXY-SM), and Klebsiella michiganensis (SXY-KM) were isolated from a pediatric patient in China. Whole-genome sequencing and resistome analysis revealed th...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-10-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034125002187 |
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| Summary: | Carbapenem resistance has a widespread globally. In this study, three bacterial strains including Escherichia coli (SXY-EC), Serratia marcescens (SXY-SM), and Klebsiella michiganensis (SXY-KM) were isolated from a pediatric patient in China. Whole-genome sequencing and resistome analysis revealed the appearance of blaNDM-1 β-lactamase gene in all these three strains, and conjugation tests confirmed its transferability. Additionally, SXY-SM and SXY-KM harbored two to three other resistance genes, while SXY-EC carried eleven. Notably, the multidrug resistance region containing blaNDM-1 in plasmid pSXY-EC_NDM1 from SXY-EC was flanked by mobile elements, potentially enabling intermolecular replicative transposition mediated by distinct insertion sequences. |
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| ISSN: | 1876-0341 |