Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin
In this paper, the preparation a number of heterocyclic compounds five membered rings like oxadiazole, imidazolidine, thiozolidine, tetrazole, azetidine 2-on. Hydrazide (1) was synthesized from the reaction of levofloxacin with hydrazine hydrate. Hydrazone compounds (2-9) were synthesized from the...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tikrit University
2023-02-01
|
| Series: | Tikrit Journal of Pure Science |
| Subjects: | |
| Online Access: | https://tjpsj.org/index.php/tjps/article/view/1244 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839631452135751680 |
|---|---|
| author | Ekram Abdullah Basheer Kalid Matny Al-jaanaby Feras Shauki Al-joboury |
| author_facet | Ekram Abdullah Basheer Kalid Matny Al-jaanaby Feras Shauki Al-joboury |
| author_sort | Ekram Abdullah Basheer |
| collection | DOAJ |
| description |
In this paper, the preparation a number of heterocyclic compounds five membered rings like oxadiazole, imidazolidine, thiozolidine, tetrazole, azetidine 2-on. Hydrazide (1) was synthesized from the reaction of levofloxacin with hydrazine hydrate. Hydrazone compounds (2-9) were synthesized from the reaction (1) with a number of aldehydes, and 3-acetyl-1,3,4-oxadiazol (10-17) was prepared from the reaction of hydrazones (2-9) with acetic anhydride, 5-oxo-2-aryl imadazoldine derivative (18-25) were prepared from the reaction of hydrazone derivatives (2-9) with glycine, while the reaction of hydrazone with thioglygolic acid gave 4-oxo-2-aryl-thiozolidine (26-33),tetrazole derivative(34-41)prepared from the reaction of hydrazone(2-9) with sodium azide in tetrahyro furan.azetidine-2-on(42-49)with chloro acetyl chloride in DMF and and in the presence of triethyl amine these compounds were characterized on bases of spectral and physical data.
|
| format | Article |
| id | doaj-art-da5f11bae6c3413d9bb79085a66dde4c |
| institution | Matheson Library |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-da5f11bae6c3413d9bb79085a66dde4c2025-07-11T15:32:39ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262023-02-0120510.25130/tjps.v20i5.1244 Synthesis a Number of Heterocyclic Compounds Derived From LevofloxacinEkram Abdullah BasheerKalid Matny Al-jaanabyFeras Shauki Al-joboury In this paper, the preparation a number of heterocyclic compounds five membered rings like oxadiazole, imidazolidine, thiozolidine, tetrazole, azetidine 2-on. Hydrazide (1) was synthesized from the reaction of levofloxacin with hydrazine hydrate. Hydrazone compounds (2-9) were synthesized from the reaction (1) with a number of aldehydes, and 3-acetyl-1,3,4-oxadiazol (10-17) was prepared from the reaction of hydrazones (2-9) with acetic anhydride, 5-oxo-2-aryl imadazoldine derivative (18-25) were prepared from the reaction of hydrazone derivatives (2-9) with glycine, while the reaction of hydrazone with thioglygolic acid gave 4-oxo-2-aryl-thiozolidine (26-33),tetrazole derivative(34-41)prepared from the reaction of hydrazone(2-9) with sodium azide in tetrahyro furan.azetidine-2-on(42-49)with chloro acetyl chloride in DMF and and in the presence of triethyl amine these compounds were characterized on bases of spectral and physical data. https://tjpsj.org/index.php/tjps/article/view/1244heterocyclic compoundssynthesizedlevofloxacin |
| spellingShingle | Ekram Abdullah Basheer Kalid Matny Al-jaanaby Feras Shauki Al-joboury Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin Tikrit Journal of Pure Science heterocyclic compounds synthesized levofloxacin |
| title | Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin |
| title_full | Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin |
| title_fullStr | Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin |
| title_full_unstemmed | Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin |
| title_short | Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin |
| title_sort | synthesis a number of heterocyclic compounds derived from levofloxacin |
| topic | heterocyclic compounds synthesized levofloxacin |
| url | https://tjpsj.org/index.php/tjps/article/view/1244 |
| work_keys_str_mv | AT ekramabdullahbasheer synthesisanumberofheterocycliccompoundsderivedfromlevofloxacin AT kalidmatnyaljaanaby synthesisanumberofheterocycliccompoundsderivedfromlevofloxacin AT ferasshaukialjoboury synthesisanumberofheterocycliccompoundsderivedfromlevofloxacin |