Impact of tranexamic acid on the efficacy of vancomycin and meropenem against periprosthetic joint infections: an in vitro analysis
Aims: This study investigated the effects of tranexamic acid (TXA) on the efficacy of vancomycin and meropenem against common periprosthetic joint infection (PJI)-associated pathogens in vitro. The aim was to uncover valuable insights that can be used for clinical decision-making and enhanced manage...
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| Format: | Article |
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The British Editorial Society of Bone & Joint Surgery
2025-07-01
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| Series: | Bone & Joint Research |
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| Online Access: | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.147.BJR-2024-0508.R1 |
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| author | Liqin Yao Youcai Ma Qiangde Hu Rui Liu Boyong Xu Xuebin Sun Li Cao Wenbo Mu |
| author_facet | Liqin Yao Youcai Ma Qiangde Hu Rui Liu Boyong Xu Xuebin Sun Li Cao Wenbo Mu |
| author_sort | Liqin Yao |
| collection | DOAJ |
| description | Aims: This study investigated the effects of tranexamic acid (TXA) on the efficacy of vancomycin and meropenem against common periprosthetic joint infection (PJI)-associated pathogens in vitro. The aim was to uncover valuable insights that can be used for clinical decision-making and enhanced management of PJI in orthopaedic surgery. Methods: We evaluated the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), minimum biofilm inhibitory concentration (MBIC), and minimum biofilm eradication concentration (MBEC) for vancomycin and meropenem, both with and without TXA, against various bacterial strains. Results: In the planktonic bacterial phase, TXA increased the MIC and MBC of vancomycin for Staphylococcus aureus and Staphylococcus epidermidis, decreased the MIC and MBC of meropenem for S. aureus, and increased the MIC and MBC of vancomycin combined with meropenem for S. aureus. In biofilms, TXA in combination with vancomycin synergistically decreased the MBIC and MBEC values of methicillin-resistant S. aureus (MRSA) and S. aureus. Conclusion: TXA influences antibiotic efficacy against both planktonic bacteria and biofilms, with effects varying by antibiotic and bacterial strain. These findings underscore the complexity of drug interactions in PJI treatment, highlighting the need for tailored therapeutic strategies based on strain-specific responses. Cite this article: Bone Joint Res 2025;14(7):601–608. |
| format | Article |
| id | doaj-art-d9e302c0135247a69c46c58c984761b1 |
| institution | Matheson Library |
| issn | 2046-3758 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | The British Editorial Society of Bone & Joint Surgery |
| record_format | Article |
| series | Bone & Joint Research |
| spelling | doaj-art-d9e302c0135247a69c46c58c984761b12025-07-30T13:39:31ZengThe British Editorial Society of Bone & Joint SurgeryBone & Joint Research2046-37582025-07-0114760160810.1302/2046-3758.147.BJR-2024-0508.R1Impact of tranexamic acid on the efficacy of vancomycin and meropenem against periprosthetic joint infections: an in vitro analysisLiqin Yao0Youcai Ma1Qiangde Hu2Rui Liu3Boyong Xu4Xuebin Sun5Li Cao6Wenbo Mu7Orthopedic Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Sports Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Sports Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Orthopaedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaAims: This study investigated the effects of tranexamic acid (TXA) on the efficacy of vancomycin and meropenem against common periprosthetic joint infection (PJI)-associated pathogens in vitro. The aim was to uncover valuable insights that can be used for clinical decision-making and enhanced management of PJI in orthopaedic surgery. Methods: We evaluated the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), minimum biofilm inhibitory concentration (MBIC), and minimum biofilm eradication concentration (MBEC) for vancomycin and meropenem, both with and without TXA, against various bacterial strains. Results: In the planktonic bacterial phase, TXA increased the MIC and MBC of vancomycin for Staphylococcus aureus and Staphylococcus epidermidis, decreased the MIC and MBC of meropenem for S. aureus, and increased the MIC and MBC of vancomycin combined with meropenem for S. aureus. In biofilms, TXA in combination with vancomycin synergistically decreased the MBIC and MBEC values of methicillin-resistant S. aureus (MRSA) and S. aureus. Conclusion: TXA influences antibiotic efficacy against both planktonic bacteria and biofilms, with effects varying by antibiotic and bacterial strain. These findings underscore the complexity of drug interactions in PJI treatment, highlighting the need for tailored therapeutic strategies based on strain-specific responses. Cite this article: Bone Joint Res 2025;14(7):601–608.https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.147.BJR-2024-0508.R1vancomycinmeropenemtranexamic acidmethicillin-resistant staphylococcus aureusstaphylococcus aureusstaphylococcus epidermidisescherichia colitranexamic acidvancomycinperiprosthetic joint infection (pji)antibioticsbiofilmsstrainsbacteriamrsaorthopaedic surgery |
| spellingShingle | Liqin Yao Youcai Ma Qiangde Hu Rui Liu Boyong Xu Xuebin Sun Li Cao Wenbo Mu Impact of tranexamic acid on the efficacy of vancomycin and meropenem against periprosthetic joint infections: an in vitro analysis Bone & Joint Research vancomycin meropenem tranexamic acid methicillin-resistant staphylococcus aureus staphylococcus aureus staphylococcus epidermidis escherichia coli tranexamic acid vancomycin periprosthetic joint infection (pji) antibiotics biofilms strains bacteria mrsa orthopaedic surgery |
| title | Impact of tranexamic acid on the efficacy of vancomycin and meropenem against periprosthetic joint infections: an in vitro analysis |
| title_full | Impact of tranexamic acid on the efficacy of vancomycin and meropenem against periprosthetic joint infections: an in vitro analysis |
| title_fullStr | Impact of tranexamic acid on the efficacy of vancomycin and meropenem against periprosthetic joint infections: an in vitro analysis |
| title_full_unstemmed | Impact of tranexamic acid on the efficacy of vancomycin and meropenem against periprosthetic joint infections: an in vitro analysis |
| title_short | Impact of tranexamic acid on the efficacy of vancomycin and meropenem against periprosthetic joint infections: an in vitro analysis |
| title_sort | impact of tranexamic acid on the efficacy of vancomycin and meropenem against periprosthetic joint infections an in vitro analysis |
| topic | vancomycin meropenem tranexamic acid methicillin-resistant staphylococcus aureus staphylococcus aureus staphylococcus epidermidis escherichia coli tranexamic acid vancomycin periprosthetic joint infection (pji) antibiotics biofilms strains bacteria mrsa orthopaedic surgery |
| url | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.147.BJR-2024-0508.R1 |
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