Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology

QR Code

Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology

BackgroundCardiovascular, Kidney and metabolic syndrome (CKM) is a complex disease, for which current therapeutic approaches have limited efficacy. This study aims to screen for potential targets and novel drugs for treating CKM using network pharmacology.MethodsUsing reverse network pharmacology, c...

Full description

Saved in:

Bibliographic Details
Main Authors:	Si’ao Wen, Ao’ni Fu, Fen Liu, Yayu You, Linkai Li, Wen Xiao, Haoran Zhong, Xiuqin Hong, Xin Zhong, Yongjun Hu, Zhengyu Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Pharmacology
Subjects:	Cardiovascular-kidney metabolic syndrome (CKM) Berberine network pharmacology “two-hit” model animal model HFpEF
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1627236/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Correction: Adverse effects of finerenone in patients with heart failure: a systematic review and meta-analysis
by: Wanqian Yu, et al.
Published: (2025-07-01)

Adverse effects of finerenone in patients with heart failure: a systematic review and meta-analysis
by: Wanqian Yu, et al.
Published: (2025-05-01)

Hospitalized patients and stimulant use-associated heart failure: importance of ejection fraction and related risk factors
by: Akshat Agrawal, et al.
Published: (2025-07-01)

The Role of Inflammation in the Pathophysiology of Heart Failure
by: Marwan Amara, et al.
Published: (2025-07-01)

Intravenous iron in heart failure: still no prognostic impact, but questions remain
by: Ibrahim El-Battrawy, et al.
Published: (2025-08-01)

EVOLUTION‐HF DEallEF: A non‐interventional study of patients with heart failure initiated on dapagliflozin: study design
by: Matthias Paul, et al.
Published: (2025-08-01)

Multi‐microRNA diagnostic panel for heart failure with preserved ejection fraction in preclinical and clinical settings
by: Reza Parvan, et al.
Published: (2025-08-01)

Atrial Fibrillation, Heart Failure Phenotypes, and Mortality Risk in the Nationwide START Registry: A Propensity Score Matching Analysis
by: Danilo Menichelli, et al.
Published: (2025-06-01)

Chronotropic Incompetence and Cardiovascular Outcomes in Patients With Heart Failure With Preserved Ejection Fraction
by: Ting‐Tse Lin, et al.
Published: (2025-07-01)

Risk of heart failure and subtypes with biomarker-calibrated protein intake: Women’s health initiative cohort study
by: Muhammad Baig, et al.
Published: (2025-09-01)

Sex differences in the association between nutritional status and in‐hospital mortality in HFpEF patients
by: Michał Czapla, et al.
Published: (2025-08-01)

Right Ventricular Myocardial Work Predicts Pulmonary Capillary Wedge Pressure Rise During Exercise in Heart Failure
by: Kuan-Chih Huang, MD, PhD, et al.
Published: (2025-08-01)

Gender-Specific Differences in Diastolic Dysfunction and HFpEF: Pathophysiology, Diagnosis, and Therapeutic Strategies
by: Francesca Coppi, et al.
Published: (2025-06-01)

MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction‐Regulating Proteins in a Rat Model of HFpEF
by: Beatrice Vahle, et al.
Published: (2025-06-01)

Exploring heart failure prevalence and dimensions: A comprehensive NT‐proBNP study in high‐risk primary care patients
by: Ahmet Celik, et al.
Published: (2025-08-01)

Prevalence and long-term outcomes of NAFLD and cardiovascular-kidney-metabolic health in the United States
by: Jian Liu, et al.
Published: (2025-09-01)

Image Descriptions for Visually Impaired Individuals to Locate Restroom Facilities
by: Cheng-Si He, et al.
Published: (2025-04-01)

Meta-analysis of the effects of levothyroxine therapy for subclinical hypothyroidism during pregnancy on offspring outcomes
by: Zhiying You, et al.
Published: (2025-07-01)

Targeting atrial fibrillation in HFpEF: the emerging role of pulsed field ablation
by: A. S. Parwani, et al.
Published: (2025-07-01)

iTRAQ protein profile analysis of soybean stems reveals new aspects critical for lodging in intercropping systems
by: Wei-guo LIU, et al.
Published: (2019-09-01)

The Well-Posedness and Ergodicity of a CIR Equation Driven by Pure Jump Noise
by: Xu Liu, et al.
Published: (2025-06-01)

History and Prediction of the Asian Monsoon and Glacial Terminations, Based on Records from the South China Sea
by: Ao, Hong, et al.
Published: (2012)

A genetic diversity assessment of starch quality traits in rice landraces from the Taihu basin, China
by: Yan AO, et al.
Published: (2016-03-01)

Introduction to Longevity Counties in China
by: Qi-feng Tang, et al.
Published: (2025-07-01)

Regulation of the non-steroid anti-inflammatory drug «Diclofenac sodium» in the air environment of populated places
by: Ya.Yu. Nikolaieva
Published: (2025-06-01)

Numerical analysis of the effect of middle-ear effusion on the sound transmission and energy absorbance of the human ear
by: Peihan Liu, et al.
Published: (2025-07-01)

Legal Deﬁnition of Irresistible Force in the Civil Law of Russia and China
by: S. Zimneva, et al.
Published: (2021-10-01)

Increase in Deglacial Ocean Heat Content Linked to Contrasts in Extratropical Warming
by: Chenyu Zhu, et al.
Published: (2025-07-01)

Numerical and experimental study on the combustion pressurization and gaseous products of propellant in a combustor
by: Chenzhuo Hao, et al.
Published: (2025-09-01)

Proteomics Identification of Differentially Expressed Leaf Proteins in Response to Setosphaeria turcica Infection in Resistant Maize
by: Xiao-li ZHANG, et al.
Published: (2014-04-01)

Design of Monocular Vision Safety Assistant System for Industrial Robot
by: WU Xiao-wen, et al.
Published: (2022-06-01)

Research on leading agricultural enterprises guiding farmers' participation in pre-production quality and safety control: evidence from the Yangtze River Delta Region of China
by: Chenying Liu, et al.
Published: (2025-07-01)

Advancements in electrochemical synthesis: Expanding from water electrolysis to dual-value-added products
by: Genxiang Wang, et al.
Published: (2025-07-01)

Opening model of natural ventilation windows for East-China Multi-span Plastic Greenhouse and studies on it
by: SI Hui-ping, et al.
Published: (2005-01-01)

High-Precision Frequency Measurement Using Digital Signal Processing
by: Liu, Ya, et al.
Published: (2011)

Inclusion interaction of cyclodextrins and 2,4-dichlorprop methyl ester enantiomers by UV spectra
by: LI Hong, et al.
Published: (2008-01-01)

Design of a Visual Communication System for Animated Characters in Virtual Reality Using Sobel Edge Detection and Motion Capture
by: Zhengyu Yang
Published: (2025-06-01)

A Cross-Chain Solution to Connect Multiple DNS Blockchains in Consensus Roots System
by: Linkai Zhu, et al.
Published: (2025-07-01)

Transcriptome analysis of hsp18.3 functions and regulatory systems using RNA-sequencing in the red flour beetle, Tribolium castaneum
by: Wen-feng XIONG, et al.
Published: (2018-05-01)

Investigation of Aegilops umbellulata for stripe rust resistance, heading date, and the contents of iron, zinc, and gluten protein
by: Zhong-ping SONG, et al.
Published: (2023-04-01)