Busulfan damages spermatogenic function by inducing orchitis.

In order to clarify injure mechanism of busulfan to spermatogenic function, we treated mice with busulfan, the testicular and epididymal weights and sperm concentration significantly decreased and the sperm malformation rate increased over time. Moreover, testicular interstitial cell infiltration, a...

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Bibliographic Details
Main Authors: Lingjun Zhao, Kaihui Wu, Shiyuan Xu, Songqi Liu, Kaimin Yuan, Dong Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0322721
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