Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′-<i>O</i>-Benzylidene Acetal Side Chain Structure as Potent α-Glucosidase Inhibitors

Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′-<i>O</i>-Benzylidene Acetal Side Chain Structure as Potent α-Glucosidase Inhibitors

A group of sulfonium and selenonium salts bearing diverse benzylidene acetal substituents on their side chain moiety were designed and synthesized. Compared with our previous study, structural modifications in this study focused on multi-substitution of the phenyl ring and bioisosteric replacements...

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Bibliographic Details
Main Authors: Xiaosong He, Jiahao Yi, Jianchen Yang, Genzoh Tanabe, Osamu Muraoka, Weijia Xie
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
α-glucosidase inhibitor
<i>Salacia</i>
sulfonium salts
selenonium salts
anti-hyperglycemic effects
Online Access:https://www.mdpi.com/1420-3049/30/13/2856
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