Toxicity Estimation of Unspecific Medicinal Antiviral Agents for Prophylaxis and Therapy of Hazard and Especially Hazard Viral Infections
Cytotoxicity of chemotherapeutics (Ribavirin®, Remantadin® and Ingavirin®), interferon (Realdiron®) and interferon inductors (Larifan®, Ridostin®, Arbidol® and Cytarabin®) was investigated with the use of persistent and diploid cell cultures. Ingavirin® and Ribavirin® from the group of the chemother...
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| Главные авторы: | , , , |
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| Формат: | Статья |
| Язык: | русский |
| Опубликовано: |
LLC "Publishing House OKI"
2020-05-01
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| Серии: | Антибиотики и Химиотерапия |
| Предметы: | |
| Online-ссылка: | https://www.antibiotics-chemotherapy.ru/jour/article/view/213 |
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| Итог: | Cytotoxicity of chemotherapeutics (Ribavirin®, Remantadin® and Ingavirin®), interferon (Realdiron®) and interferon inductors (Larifan®, Ridostin®, Arbidol® and Cytarabin®) was investigated with the use of persistent and diploid cell cultures. Ingavirin® and Ribavirin® from the group of the chemotherapeutics and Razifan® and Ridostin® from the group of the interferon inducrors showed the lowest toxicity. Light microscopy revealed no visible cytopathic changes in the investigation cell cultures exposed to maximum concentrations (≥106 IU) of Realdiron®. In vivo acute toxicity investigation demonstrated that in a concentration of 106 IU per animal weight Realdiron® was not toxic for the albino mice and chinchilla rabbits. The maximum tolerance doses for the albino mice were the following: ≥3000 mg/kg of Ingavirin®, 401.25 mg/kg of Arbidol®, 170 mg/kg of Ribavirin®, ≥100 mg/kg of Larifan® and ≥100 mg/kg of Ridostin®. |
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| ISSN: | 0235-2990 |