A rare HCN4 variant combined with sick sinus syndrome, left ventricular noncompaction, and complex congenital heart disease

The hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4) gene has been reported to regulate the spontaneous depolarization of sinoatrial node cells. A novel HCN4 mutation (c.2036 G>A) may lead to sick sinus syndrome. The green fluorescent protein (GFP) and either the wil...

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Bibliographic Details
Main Authors: Fengxiao Zhang, Ning Zhao, Lin Wang, Hua Peng, Ying Jiang, Min Cheng, Feng Zhu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Channels
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Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2025.2517851
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