Fluorescent diagnostics of non-melanoma skin cancer
Fluorescent diagnostics is a promising method for diagnosing non-melanocytic skin tumors, which makes it possible to identify clinically undetectable skin cancer foci and clarify the margin of the tumor lesion. The main drugs for fluorescent diagnostics are drugs based on 5-aminolevulinic acid and i...
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2023-01-01
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| Series: | Biomedical Photonics |
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| Online Access: | https://www.pdt-journal.com/jour/article/view/566 |
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| author | E. V. Filonenko V. I. Ivanova-Radkevich |
| author_facet | E. V. Filonenko V. I. Ivanova-Radkevich |
| author_sort | E. V. Filonenko |
| collection | DOAJ |
| description | Fluorescent diagnostics is a promising method for diagnosing non-melanocytic skin tumors, which makes it possible to identify clinically undetectable skin cancer foci and clarify the margin of the tumor lesion. The main drugs for fluorescent diagnostics are drugs based on 5-aminolevulinic acid and its methyl ester. Sensitivity indicators of fluorescent diagnostics in basal cell, squamous cell carcinoma and extramammary Paget’s disease reach 79.0-100.0%, speci city – 55.6-100%. But the effectiveness of this method may be reduced due to hyperkeratinization, keratinization, and the presence of necrotic tissue on the surface of tumor foci. Comparative studies of the results of fluorescent diagnostics and histological mapping during tumor removal using Mohs micrographic surgery showed approximately equal results in the determining of the tumor edges by these methods, which indicates that safe and technically easily performed fluorescent diagnostics can serve as a good alternative to Mohs micrographic surgery, one of the most accurate, but rather labor-intensive and technically complex method for determining the margin of skin cancer foci. |
| format | Article |
| id | doaj-art-d95b4d9a68c645df94c34b4335a7efb6 |
| institution | Matheson Library |
| issn | 2413-9432 |
| language | Russian |
| publishDate | 2023-01-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj-art-d95b4d9a68c645df94c34b4335a7efb62025-08-04T13:14:24ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322023-01-01114324010.24931/2413-9432-2022-11-4-32-40266Fluorescent diagnostics of non-melanoma skin cancerE. V. Filonenko0V. I. Ivanova-Radkevich1P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationPeoples’ Friendship University of Russia (RUDN University)Fluorescent diagnostics is a promising method for diagnosing non-melanocytic skin tumors, which makes it possible to identify clinically undetectable skin cancer foci and clarify the margin of the tumor lesion. The main drugs for fluorescent diagnostics are drugs based on 5-aminolevulinic acid and its methyl ester. Sensitivity indicators of fluorescent diagnostics in basal cell, squamous cell carcinoma and extramammary Paget’s disease reach 79.0-100.0%, speci city – 55.6-100%. But the effectiveness of this method may be reduced due to hyperkeratinization, keratinization, and the presence of necrotic tissue on the surface of tumor foci. Comparative studies of the results of fluorescent diagnostics and histological mapping during tumor removal using Mohs micrographic surgery showed approximately equal results in the determining of the tumor edges by these methods, which indicates that safe and technically easily performed fluorescent diagnostics can serve as a good alternative to Mohs micrographic surgery, one of the most accurate, but rather labor-intensive and technically complex method for determining the margin of skin cancer foci.https://www.pdt-journal.com/jour/article/view/566uorescent diagnosticsskin cancerbasal cell carcinomasquamous cell carcinomapaget’s extramammary deseasetumor margin5-aminolevulinic acid5-aminolevulinic acid methyl ester |
| spellingShingle | E. V. Filonenko V. I. Ivanova-Radkevich Fluorescent diagnostics of non-melanoma skin cancer Biomedical Photonics uorescent diagnostics skin cancer basal cell carcinoma squamous cell carcinoma paget’s extramammary desease tumor margin 5-aminolevulinic acid 5-aminolevulinic acid methyl ester |
| title | Fluorescent diagnostics of non-melanoma skin cancer |
| title_full | Fluorescent diagnostics of non-melanoma skin cancer |
| title_fullStr | Fluorescent diagnostics of non-melanoma skin cancer |
| title_full_unstemmed | Fluorescent diagnostics of non-melanoma skin cancer |
| title_short | Fluorescent diagnostics of non-melanoma skin cancer |
| title_sort | fluorescent diagnostics of non melanoma skin cancer |
| topic | uorescent diagnostics skin cancer basal cell carcinoma squamous cell carcinoma paget’s extramammary desease tumor margin 5-aminolevulinic acid 5-aminolevulinic acid methyl ester |
| url | https://www.pdt-journal.com/jour/article/view/566 |
| work_keys_str_mv | AT evfilonenko fluorescentdiagnosticsofnonmelanomaskincancer AT viivanovaradkevich fluorescentdiagnosticsofnonmelanomaskincancer |