Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site

QR Code

Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site

Saved in:

Bibliographic Details
Main Authors:	Sarah E. Border, Leilani M. Lotti Diaz, Rasmiah Amer, Abigail M. Noonchester, Kayla S. Kucway, Michael Fleisher, Joseph P. Fernandez, Alex R. Lovins, Thomas S. Corrigan, Ana K. Serrano, Conor R. Caffrey, Anthony J. O’Donoghue, Don M. Benson, Christopher M. Hadad, Özlem Doğan Ekici
Format:	Article
Language:	English
Published:	American Chemical Society 2025-07-01
Series:	ACS Omega
Online Access:	https://doi.org/10.1021/acsomega.5c02128
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Catalytic Innovations in the Aza-Michael Reaction: An Experimental Benchmarking Focused on Sustainable Approaches
by: Silvia Izquierdo, et al.
Published: (2025-06-01)

Targeting the Proteasome in Melanoma
by: Sorolla, Anabel, et al.
Published: (2011)

Synthesis of New Aza-Heterocyclic Based on 2-Pyridone
by: Ikram Baba-Ahmed, et al.
Published: (2024-11-01)

Michael Acceptor Compounds as Hemoglobin Oxygen Affinity Modulators for Reversing Sickling of Red Blood Cells
by: Khadijah A. Mohammad, et al.
Published: (2025-05-01)

Gemstones /
by: O'Donoghue, Michael
Published: (1988)

Quartz /
by: O'Donoghue, Michael
Published: (1987)

DETERMINATION OF THE ACCEPTOR MOLECULES CONCENTRATION IN THE TRIPLET STATE ON EXCITATION OF DONOR-ACCEPTOR PAIRS BY RECURRENT PULSES
by: Natal’ya Vladimirovna Zhdanova, et al.
Published: (2022-09-01)

The effect of intramolecular donor–acceptor moieties with donor–π-bridge–acceptor structure on the solar photovoltaic performance
by: T. L. Wang, et al.
Published: (2015-10-01)

Donor-Acceptor Conjugated Polymers and Their Nanocomposites for Photonic Applications
by: Kumar, D. Udaya, et al.
Published: (2012)

Reduced Fetal Movements
by: Unterscheider, Julia, et al.
Published: (2012)

Proteasome Targeted Therapies in Rheumatoid Arthritis
by: Ahmed, Aisha Siddiqah
Published: (2012)

The Ubiquitin-Proteasome System and DNA Repair
by: Falaschetti, Christine A., et al.
Published: (2011)

Proteasome Inhibitors in the Treatment of Multiple Myeloma
by: Crawford, Lisa J., et al.
Published: (2012)

MELASMA SHOW UP IN CONTRACEPTIVE PILLS ACCEPTORS
by: Cahya Novenita Azzahra, et al.
Published: (2021-01-01)

Improvement in Wrinkles by a Fairy Chemical, 2-Aza-8-oxohypoxanthine
by: Hisae Aoshima, et al.
Published: (2025-06-01)

The Ubiquitin-Proteasomal System and Blood Cancer Therapy
by: Mao, Xinliang, et al.
Published: (2012)

New proteasome inhibitors in the management of multiple myeloma
by: S. V. Semochkin
Published: (2019-07-01)

Synthesis, Stability, and Biological Evaluation of Novel Aminoderivatives Incorporating the Aza-Acridine Scaffold
by: Maria Karelou, et al.
Published: (2025-06-01)

Chymotrypsin-like and caspase-like proteasome activities in breast cancer
by: E. E. Shashova, et al.
Published: (2016-02-01)

Clinical Risk Factors for Preterm Birth
by: Offiah, Ifeoma, et al.
Published: (2012)

Art Therapy Experiential Workshops During Work Hours to Promote Doctors’ Wellbeing – A Quantitative Analysis
by: Safia Zaffarullah, et al.
Published: (2025-06-01)

Compensation Relationships in the Solvation Thermodynamics of Proton Acceptors in Aliphatic Alcohols
by: Boris N. Solomonov, et al.
Published: (2025-06-01)

Proteasomal diseases are a new branch of autoinflammatory pathology
by: Evgeny Stanislavovich Fedorov
Published: (2013-12-01)

The Proteasome as a Therapeutic Target in Chronic Myeloid Leukemia
by: Pérez-Roger, Ignacio, et al.
Published: (2011)

Proteasome activity and subunit composition in endometrial hyperplasia and cancer
by: L. V. Spirina, et al.
Published: (2014-08-01)

Role of proteasome system in prognosis of breast cancer progression
by: E. E. Shashova, et al.
Published: (2018-09-01)

ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESIS
by: E. V. Ivanova, et al.
Published: (2016-02-01)

Proteasome expression and activity in cancer and cancer stem cells
by: Ioannis A Voutsadakis
Published: (2017-03-01)

PROTEASOMAL AND CALPAIN PROTEOLYSIS SYSTEMS IN DIFFERENT MOLECULAR SUBTYPES OF BREAST CANCER
by: E. E. Shashova, et al.
Published: (2017-07-01)

Role of the ubiquitin-proteasome system in the progression of oral squamous cell carcinoma
by: D. E. Mikhalev, et al.
Published: (2021-07-01)

POSSIBLE ROLE OF LIVER PROTEASOMES IN THE REALIZATION OF MECHANISMS OF TRANSPLANTATION TOLERANCE
by: G. A. Bozhok, et al.
Published: (2011-06-01)

Proteasome inhibitors: situation and prospects (literature review and own data)
by: A. A. Rukavitsyn, et al.
Published: (2016-10-01)

THE INTRACELLULAR AND CIRCULATING POOLS OF PROTEASOMES: THE VALUE AT CANCER IN DIFFERENT LOCATIONS
by: E. E. Shashova, et al.
Published: (2016-02-01)

Catalyst-Free Spontaneous Aza-Mannich/Lactamization Cascade Reaction: Easy Access to Polycyclic δ-Lactams
by: Antonia Di Mola, et al.
Published: (2025-06-01)

Molecular Interactions of Some Free Base Porphyrins with σ- and π-Acceptor Molecules
by: Zabardasti, Abedien
Published: (2012)

Rigid and flexible azopolymers modified with donor/acceptor groups. Synthesis and photochromic behavior
Published: (2011-11-01)

THE ACTIVITY OF CIRCULATING PROTEASOMES IN TUMOR AND PRECANCEROUS DISEASES OF THE HEAD AND NECK ORGANS
by: E. A. Sidenko, et al.
Published: (2021-05-01)

PROTEASOMES AND EXOSOMES IN OVARIAN CANCER: RALATION WITH DISEASE PROGNOSIS AND CLINICAL OUTCOME
by: N. V. Yunusova, et al.
Published: (2016-02-01)

Synthesis of an aza[5]helicene-incorporated macrocyclic heteroarene via oxidation of an o-phenylene-pyrrole-thiophene icosamer
by: Yusuke Matsuo, et al.
Published: (2025-07-01)

Modulating Polaron Behavior in PM6 Blends with Nonfullerene and Fullerene Acceptors: The Importance of Singlet Energy Transfer
by: Rebecca Harris, et al.
Published: (2025-07-01)