Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma

Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma

Abstract Background Temozolomide (TMZ), which is an alkylating agent, is the standard chemotherapeutic drug used for glioma treatment. However, the development of resistance to TMZ limits its efficacy. Thus, identifying novel therapeutic targets is necessary. Methods In this study, the levels of mid...

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Bibliographic Details
Main Authors: Xiaonan Xi, Xiaojing Ding, Qianqian Wang, Ning Liu, Bangmao Wang, Genbei Wang, Weilong Zhong, Yaxin Lu
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Clinical and Translational Medicine
Subjects:
ACT001
drug resistance
glioma
MDK
protein complex
Online Access:https://doi.org/10.1002/ctm2.70359
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