Prostate cancer inducing secondary linitis plastica of the rectum: a rare case report and literature review

Prostate cancer inducing secondary linitis plastica of the rectum: a rare case report and literature review

BackgroundProstate cancer, the most prevalent male malignancy in Western countries, seldom presents as secondary rectal linitis plastica (RLP).Case presentationWe present an 82-year-old man with a 6-month history of altered bowel habits, narrowed stools, and mucous discharge, with absent lower urina...

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Main Authors: Dongpo Zhang, Jun Li, Tao Sun, Ling Zhang, Lian Wang, Quan Gan, Xiaoxiao Xing, Yong Zhang, Yue Wang, Daixiang Liao, Junyi Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
prostate cancer
secondary rectal linitis plastica
rectal adenocarcinoma
PSA
MRI
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1597367/full
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Summary:BackgroundProstate cancer, the most prevalent male malignancy in Western countries, seldom presents as secondary rectal linitis plastica (RLP).Case presentationWe present an 82-year-old man with a 6-month history of altered bowel habits, narrowed stools, and mucous discharge, with absent lower urinary tract symptoms. Serum Prostate Specific Antigen (PSA) was markedly elevated (392 ng/mL). Imaging demonstrated circumferential rectal thickening and a prostatic mass invading the bladder. MRI revealed a “target sign” with associated diffusion restriction. Colonoscopy identified circumferential mucosal protrusions resembling grape-like clusters (Nice Band Imaging (NBI) International Colorectal Endoscopic (NICE) type 3). Deep biopsies confirmed prostatic adenocarcinoma (Gleason score 4 + 3 = 7).DiagnosisA multidisciplinary team confirmed the diagnosis of prostate cancer with secondary RLP.TreatmentCombination therapy (prophylactic colostomy, leuprorelin, and abiraterone) reduced PSA from 392 to 2.16 ng/mL within 8 months.ConclusionsRLP may mimic various gastrointestinal disorders clinically. Clinicians should consider RLP in elderly men presenting with gastrointestinal symptoms. Definitive diagnosis requires the integration of multi-modality imaging, endoscopy, and histopathological biopsy.
ISSN:2234-943X

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