Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases
Abstract Transcriptional regulation plays a pivotal role in coordinating the complex morphogenetic and molecular events involved in heart development and function. In the early stages of cardiovascular diseases (CVDs), the Mediator complex (MED) performs a variety of essential functions. While initi...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02720-2 |
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| author | Concetta Schiano Claudio Napoli |
| author_facet | Concetta Schiano Claudio Napoli |
| author_sort | Concetta Schiano |
| collection | DOAJ |
| description | Abstract Transcriptional regulation plays a pivotal role in coordinating the complex morphogenetic and molecular events involved in heart development and function. In the early stages of cardiovascular diseases (CVDs), the Mediator complex (MED) performs a variety of essential functions. While initial studies focused on correlating MED components with specific CVDs, more recent research has shifted toward a deeper exploration of the MED's role in the early pathogenesis of these diseases. This review highlights the latest findings published between January 2018 and February 2025, with a particular focus on the protein subunits MED1, MED12, MED13, MED13L, MED15, and MED23, and their implications in various cardiovascular pathologies. The MED complex is a crucial regulator of gene transcription, bridging transcription factors and RNA polymerase II. In “-omic” sciences, studying MED functions is essential to understanding molecular interactions that regulate gene expression. Within precision medicine, the MED complex is a key node in gene expression networks. Its study within the -omic framework can provide valuable insights into how molecular interactions shape cellular processes in both health and disease, ultimately enhancing the diagnosis, understanding, and treatment of CVDs through personalized medicine. Graphical abstract |
| format | Article |
| id | doaj-art-d819c84dbdba45e8a8c8f1a59fbb6f48 |
| institution | Matheson Library |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-d819c84dbdba45e8a8c8f1a59fbb6f482025-06-29T11:08:34ZengBMCEuropean Journal of Medical Research2047-783X2025-06-0130111510.1186/s40001-025-02720-2Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseasesConcetta Schiano0Claudio Napoli1Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania Luigi VanvitelliDepartment of Advanced Medical and Surgical Sciences (DAMSS), University of Campania Luigi VanvitelliAbstract Transcriptional regulation plays a pivotal role in coordinating the complex morphogenetic and molecular events involved in heart development and function. In the early stages of cardiovascular diseases (CVDs), the Mediator complex (MED) performs a variety of essential functions. While initial studies focused on correlating MED components with specific CVDs, more recent research has shifted toward a deeper exploration of the MED's role in the early pathogenesis of these diseases. This review highlights the latest findings published between January 2018 and February 2025, with a particular focus on the protein subunits MED1, MED12, MED13, MED13L, MED15, and MED23, and their implications in various cardiovascular pathologies. The MED complex is a crucial regulator of gene transcription, bridging transcription factors and RNA polymerase II. In “-omic” sciences, studying MED functions is essential to understanding molecular interactions that regulate gene expression. Within precision medicine, the MED complex is a key node in gene expression networks. Its study within the -omic framework can provide valuable insights into how molecular interactions shape cellular processes in both health and disease, ultimately enhancing the diagnosis, understanding, and treatment of CVDs through personalized medicine. Graphical abstracthttps://doi.org/10.1186/s40001-025-02720-2Cardiovascular diseasesEpigeneticsMediator complexPrecision medicineTranscriptional regulation |
| spellingShingle | Concetta Schiano Claudio Napoli Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases European Journal of Medical Research Cardiovascular diseases Epigenetics Mediator complex Precision medicine Transcriptional regulation |
| title | Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases |
| title_full | Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases |
| title_fullStr | Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases |
| title_full_unstemmed | Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases |
| title_short | Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases |
| title_sort | mediator complex update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases |
| topic | Cardiovascular diseases Epigenetics Mediator complex Precision medicine Transcriptional regulation |
| url | https://doi.org/10.1186/s40001-025-02720-2 |
| work_keys_str_mv | AT concettaschiano mediatorcomplexupdateofkeyinsightsintotranscriptionalregulationofancestralframeworkanditsroleincardiovasculardiseases AT claudionapoli mediatorcomplexupdateofkeyinsightsintotranscriptionalregulationofancestralframeworkanditsroleincardiovasculardiseases |