Sadchikov Pavel E. Features of Molecular Sensitisation Profile in Infants with Risk of Allergic Diseases
Background. For now, there is little data on sensitivity features to specific allergen antigens in infants with initial allergy manifestations.Objective. The aim of the study is to determine the features of the primary molecular sensitisation profile in infants with risk of atopic disease according...
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"Paediatrician" Publishers LLC
2023-01-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/3087 |
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| author | Irina A. Belyayeva Tatyana V. Turti Leyla S. Namazova-Baranova Elena P. Bombardirova Elena A. Vishneva Elena V. Kaytukova Kamilla E. Efendieva R. A. Shukenbaeva Pavel E. Sadchikov |
| author_facet | Irina A. Belyayeva Tatyana V. Turti Leyla S. Namazova-Baranova Elena P. Bombardirova Elena A. Vishneva Elena V. Kaytukova Kamilla E. Efendieva R. A. Shukenbaeva Pavel E. Sadchikov |
| author_sort | Irina A. Belyayeva |
| collection | DOAJ |
| description | Background. For now, there is little data on sensitivity features to specific allergen antigens in infants with initial allergy manifestations.Objective. The aim of the study is to determine the features of the primary molecular sensitisation profile in infants with risk of atopic disease according to their postnatal age.Methods. Full-term infants with burdened familial allergic history and/or skin/gastrointestinal allergy symptoms were examined: Group 1 — 50 children, age — 2.0 [1.0–3.0] months; Group 2 — 35 children, age — 9.0 [8.0–11.0] months.Results. The hereditary atopy risk was observed in 74% of cases (37/50) in Group 1 and in 71% of cases (25/35) in Group 2. 38% of children (19/50) in Group 1 were breastfed, in Group 2 — 60% of children (21/35). Supplemental feeding was implemented in 5.5 [5.0–6.0] months. Sensitisation was reported in 10% and 37% of children. Children of Group 1 were sensitised to food allergen antigens: cow's milk/meat (Bos d 6, Bos d 8), egg-white (Gal d 1, Gal d 2, Gal d 3), soybeans (Gly m 6), shrimps (Pen m 4); airborne allergens: house dust mite (Blo t 5, Der h 10), Anisakidae (Ani s 3), cockroach (Bla g 7). Children of Group 2 were sensitised to food allergen antigens: cow's milk (Bos d 6), egg-white (Gal d 1, Gal d 2), soybeans (Gly m 6), peanut (Ara h 1, Ara h 2, Ara h 6), kiwi (Act d 1), corn (Tri a 19); airborne allergens: cat (Fel d 1, Fel d 4), birch pollen (Bet v 1). Polyvalent sensitisation was revealed in 4% and 6% of cases, respectively.Conclusion. Infants have much wider range of allergens to which they are sensitive than it is commonly believed. Beside obligate food allergens, sensitisation can be caused by airborne allergens: house dust mites, epidermal, birch pollen; crossreactive component — tropomyosin. |
| format | Article |
| id | doaj-art-d817a4dbf8f4434c8a1e37e62635fde1 |
| institution | Matheson Library |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | "Paediatrician" Publishers LLC |
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| series | Вопросы современной педиатрии |
| spelling | doaj-art-d817a4dbf8f4434c8a1e37e62635fde12025-08-04T13:09:42Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352023-01-0121649350010.15690/vsp.v21i6.24962076Sadchikov Pavel E. Features of Molecular Sensitisation Profile in Infants with Risk of Allergic DiseasesIrina A. Belyayeva0Tatyana V. Turti1Leyla S. Namazova-Baranova2Elena P. Bombardirova3Elena A. Vishneva4Elena V. Kaytukova5Kamilla E. Efendieva6R. A. Shukenbaeva7Pavel E. Sadchikov8Morozovskaya Children’s City Hospital; Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical ManagementResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityBackground. For now, there is little data on sensitivity features to specific allergen antigens in infants with initial allergy manifestations.Objective. The aim of the study is to determine the features of the primary molecular sensitisation profile in infants with risk of atopic disease according to their postnatal age.Methods. Full-term infants with burdened familial allergic history and/or skin/gastrointestinal allergy symptoms were examined: Group 1 — 50 children, age — 2.0 [1.0–3.0] months; Group 2 — 35 children, age — 9.0 [8.0–11.0] months.Results. The hereditary atopy risk was observed in 74% of cases (37/50) in Group 1 and in 71% of cases (25/35) in Group 2. 38% of children (19/50) in Group 1 were breastfed, in Group 2 — 60% of children (21/35). Supplemental feeding was implemented in 5.5 [5.0–6.0] months. Sensitisation was reported in 10% and 37% of children. Children of Group 1 were sensitised to food allergen antigens: cow's milk/meat (Bos d 6, Bos d 8), egg-white (Gal d 1, Gal d 2, Gal d 3), soybeans (Gly m 6), shrimps (Pen m 4); airborne allergens: house dust mite (Blo t 5, Der h 10), Anisakidae (Ani s 3), cockroach (Bla g 7). Children of Group 2 were sensitised to food allergen antigens: cow's milk (Bos d 6), egg-white (Gal d 1, Gal d 2), soybeans (Gly m 6), peanut (Ara h 1, Ara h 2, Ara h 6), kiwi (Act d 1), corn (Tri a 19); airborne allergens: cat (Fel d 1, Fel d 4), birch pollen (Bet v 1). Polyvalent sensitisation was revealed in 4% and 6% of cases, respectively.Conclusion. Infants have much wider range of allergens to which they are sensitive than it is commonly believed. Beside obligate food allergens, sensitisation can be caused by airborne allergens: house dust mites, epidermal, birch pollen; crossreactive component — tropomyosin.https://vsp.spr-journal.ru/jour/article/view/3087infantssigefood allergysensitisationimmunocap isac |
| spellingShingle | Irina A. Belyayeva Tatyana V. Turti Leyla S. Namazova-Baranova Elena P. Bombardirova Elena A. Vishneva Elena V. Kaytukova Kamilla E. Efendieva R. A. Shukenbaeva Pavel E. Sadchikov Sadchikov Pavel E. Features of Molecular Sensitisation Profile in Infants with Risk of Allergic Diseases Вопросы современной педиатрии infants sige food allergy sensitisation immunocap isac |
| title | Sadchikov Pavel E. Features of Molecular Sensitisation Profile in Infants with Risk of Allergic Diseases |
| title_full | Sadchikov Pavel E. Features of Molecular Sensitisation Profile in Infants with Risk of Allergic Diseases |
| title_fullStr | Sadchikov Pavel E. Features of Molecular Sensitisation Profile in Infants with Risk of Allergic Diseases |
| title_full_unstemmed | Sadchikov Pavel E. Features of Molecular Sensitisation Profile in Infants with Risk of Allergic Diseases |
| title_short | Sadchikov Pavel E. Features of Molecular Sensitisation Profile in Infants with Risk of Allergic Diseases |
| title_sort | sadchikov pavel e features of molecular sensitisation profile in infants with risk of allergic diseases |
| topic | infants sige food allergy sensitisation immunocap isac |
| url | https://vsp.spr-journal.ru/jour/article/view/3087 |
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