Systematic review: effect of lipid and lipoprotein profiles on atherosclerosis and cardiovascular disease risk in premenopausal and postmenopausal women
<p>Understanding the relationship between lipid profiles and cardiovascular health is crucial, particularly in the context of atherosclerosis, a major cause of cardiovascular diseases. Dyslipidemia, characterized by high LDL cholesterol and triglycerides and low HDL cholesterol, is a significa...
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Academy Publishing Center
2024-09-01
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| Series: | Advances in Medical, Pharmaceutical and Dental Research |
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| Online Access: | http://apc.aast.edu/ojs/index.php/AMPDR/article/view/931 |
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| author | Avinash Namdeo Jadhao Anita Shivaji Chalak Sandip Deepak Lambe |
| author_facet | Avinash Namdeo Jadhao Anita Shivaji Chalak Sandip Deepak Lambe |
| author_sort | Avinash Namdeo Jadhao |
| collection | DOAJ |
| description | <p>Understanding the relationship between lipid profiles and cardiovascular health is crucial, particularly in the context of atherosclerosis, a major cause of cardiovascular diseases. Dyslipidemia, characterized by high LDL cholesterol and triglycerides and low HDL cholesterol, is a significant contributor to atherosclerosis. In women, menopause shifts the lipid profile from a protective to an atherogenic one due to reduced estrogen levels, increasing cardiovascular risk. Additionally, surgical procedures like hysterectomy with or without oophorectomy, which cause abrupt declines in estrogen, further disrupt lipid profiles. Among 243 initially identified publications, 15 were thoroughly reviewed, leading to the inclusion of 9 studies. These studies show that surgical menopause typically results in increased total cholesterol, LDL-C, and triglycerides, and decreased HDL-C, heightening cardiovascular risk. Effective monitoring and management of lipid profiles post-surgery are essential, and ovarian conservation during hysterectomy may mitigate some adverse lipid effects. Further longitudinal studies and personalized interventions are needed to enhance cardiovascular health in women undergoing surgical menopause.</p><p> </p><p><strong>Received: 17 July 2024 </strong></p><p><strong>Accepted: 21 August 2024 </strong></p><p><strong>Published: 09 September 2024</strong></p> |
| format | Article |
| id | doaj-art-d7a0a46f3a8b4ae9898fca70366f8ab5 |
| institution | Matheson Library |
| issn | 2812-488X 2812-4898 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Academy Publishing Center |
| record_format | Article |
| series | Advances in Medical, Pharmaceutical and Dental Research |
| spelling | doaj-art-d7a0a46f3a8b4ae9898fca70366f8ab52025-07-09T11:41:27ZengAcademy Publishing CenterAdvances in Medical, Pharmaceutical and Dental Research2812-488X2812-48982024-09-0142859210.21622/AMPDR.2024.04.2.931378Systematic review: effect of lipid and lipoprotein profiles on atherosclerosis and cardiovascular disease risk in premenopausal and postmenopausal womenAvinash Namdeo Jadhao0Anita Shivaji Chalak1Sandip Deepak Lambe2Associate Professor Department of Biochemistry, Principal contact for editorial correspondence, Seth GSMC & KEMH Parel Mumbai, India.Professor and Head, Department of Biochemistry, Seth GSMC & KEMH Parel Mumbai, India.Professor and Head, Department of Biochemistry, SMBT Nashik, India.<p>Understanding the relationship between lipid profiles and cardiovascular health is crucial, particularly in the context of atherosclerosis, a major cause of cardiovascular diseases. Dyslipidemia, characterized by high LDL cholesterol and triglycerides and low HDL cholesterol, is a significant contributor to atherosclerosis. In women, menopause shifts the lipid profile from a protective to an atherogenic one due to reduced estrogen levels, increasing cardiovascular risk. Additionally, surgical procedures like hysterectomy with or without oophorectomy, which cause abrupt declines in estrogen, further disrupt lipid profiles. Among 243 initially identified publications, 15 were thoroughly reviewed, leading to the inclusion of 9 studies. These studies show that surgical menopause typically results in increased total cholesterol, LDL-C, and triglycerides, and decreased HDL-C, heightening cardiovascular risk. Effective monitoring and management of lipid profiles post-surgery are essential, and ovarian conservation during hysterectomy may mitigate some adverse lipid effects. Further longitudinal studies and personalized interventions are needed to enhance cardiovascular health in women undergoing surgical menopause.</p><p> </p><p><strong>Received: 17 July 2024 </strong></p><p><strong>Accepted: 21 August 2024 </strong></p><p><strong>Published: 09 September 2024</strong></p>http://apc.aast.edu/ojs/index.php/AMPDR/article/view/931lipid metabolism, dyslipidemia ,hysterectomy, oophorectomy, cardiovascular risk. |
| spellingShingle | Avinash Namdeo Jadhao Anita Shivaji Chalak Sandip Deepak Lambe Systematic review: effect of lipid and lipoprotein profiles on atherosclerosis and cardiovascular disease risk in premenopausal and postmenopausal women Advances in Medical, Pharmaceutical and Dental Research lipid metabolism, dyslipidemia ,hysterectomy, oophorectomy, cardiovascular risk. |
| title | Systematic review: effect of lipid and lipoprotein profiles on atherosclerosis and cardiovascular disease risk in premenopausal and postmenopausal women |
| title_full | Systematic review: effect of lipid and lipoprotein profiles on atherosclerosis and cardiovascular disease risk in premenopausal and postmenopausal women |
| title_fullStr | Systematic review: effect of lipid and lipoprotein profiles on atherosclerosis and cardiovascular disease risk in premenopausal and postmenopausal women |
| title_full_unstemmed | Systematic review: effect of lipid and lipoprotein profiles on atherosclerosis and cardiovascular disease risk in premenopausal and postmenopausal women |
| title_short | Systematic review: effect of lipid and lipoprotein profiles on atherosclerosis and cardiovascular disease risk in premenopausal and postmenopausal women |
| title_sort | systematic review effect of lipid and lipoprotein profiles on atherosclerosis and cardiovascular disease risk in premenopausal and postmenopausal women |
| topic | lipid metabolism, dyslipidemia ,hysterectomy, oophorectomy, cardiovascular risk. |
| url | http://apc.aast.edu/ojs/index.php/AMPDR/article/view/931 |
| work_keys_str_mv | AT avinashnamdeojadhao systematicrevieweffectoflipidandlipoproteinprofilesonatherosclerosisandcardiovasculardiseaseriskinpremenopausalandpostmenopausalwomen AT anitashivajichalak systematicrevieweffectoflipidandlipoproteinprofilesonatherosclerosisandcardiovasculardiseaseriskinpremenopausalandpostmenopausalwomen AT sandipdeepaklambe systematicrevieweffectoflipidandlipoproteinprofilesonatherosclerosisandcardiovasculardiseaseriskinpremenopausalandpostmenopausalwomen |