Marchiafava-Bignami disease as a cause of toxic leukoencephalopathy in a 27-year-old patient: a case report
Marchiafava-Bignami disease (MBD) is an uncommon neurological disorder characterized by corpus callosum demyelination and necrosis, primarily associated with alcohol use disorder and vitamin deficiencies, notably thiamine. We present the case of a 27-year-old female who was diagnosed by MRI after de...
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Taylor & Francis Group
2024-12-01
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| Series: | Toxicology Communications |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/24734306.2024.2335843 |
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| author | David Kuai Ethan Leng Emily Kiernan |
| author_facet | David Kuai Ethan Leng Emily Kiernan |
| author_sort | David Kuai |
| collection | DOAJ |
| description | Marchiafava-Bignami disease (MBD) is an uncommon neurological disorder characterized by corpus callosum demyelination and necrosis, primarily associated with alcohol use disorder and vitamin deficiencies, notably thiamine. We present the case of a 27-year-old female who was diagnosed by MRI after developing stroke-like symptoms, and was found to have undetectable serum thiamine concentrations, likely due to alcohol use disorder and noncompliance with prescribed vitamin supplements after Roux-en-Y gastric bypass surgery. She was prescribed thiamine supplementation, and upon follow-up one month later, she had no residual neurological deficits. MBD is a rare cause of stroke-like symptoms, and thorough medical and surgical history is needed in patients who may not be in the typical age range for development of the disease. |
| format | Article |
| id | doaj-art-d74d6f4679f3426e9fe6228cb1a3fc8c |
| institution | Matheson Library |
| issn | 2473-4306 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Toxicology Communications |
| spelling | doaj-art-d74d6f4679f3426e9fe6228cb1a3fc8c2025-07-07T12:16:55ZengTaylor & Francis GroupToxicology Communications2473-43062024-12-018110.1080/24734306.2024.2335843Marchiafava-Bignami disease as a cause of toxic leukoencephalopathy in a 27-year-old patient: a case reportDavid Kuai0Ethan Leng1Emily Kiernan2Department of Emergency Medicine, Section of Medical Toxicology, Emory University School of Medicine, Atlanta, Georgia, USADepartment of Radiology, Emory University School of Medicine, Atlanta, Georgia, USADepartment of Emergency Medicine, Section of Medical Toxicology, Emory University School of Medicine, Atlanta, Georgia, USAMarchiafava-Bignami disease (MBD) is an uncommon neurological disorder characterized by corpus callosum demyelination and necrosis, primarily associated with alcohol use disorder and vitamin deficiencies, notably thiamine. We present the case of a 27-year-old female who was diagnosed by MRI after developing stroke-like symptoms, and was found to have undetectable serum thiamine concentrations, likely due to alcohol use disorder and noncompliance with prescribed vitamin supplements after Roux-en-Y gastric bypass surgery. She was prescribed thiamine supplementation, and upon follow-up one month later, she had no residual neurological deficits. MBD is a rare cause of stroke-like symptoms, and thorough medical and surgical history is needed in patients who may not be in the typical age range for development of the disease.https://www.tandfonline.com/doi/10.1080/24734306.2024.2335843Marchiafava-Bignami diseasethiaminetoxic leukoencephalopathyMRIcase report |
| spellingShingle | David Kuai Ethan Leng Emily Kiernan Marchiafava-Bignami disease as a cause of toxic leukoencephalopathy in a 27-year-old patient: a case report Toxicology Communications Marchiafava-Bignami disease thiamine toxic leukoencephalopathy MRI case report |
| title | Marchiafava-Bignami disease as a cause of toxic leukoencephalopathy in a 27-year-old patient: a case report |
| title_full | Marchiafava-Bignami disease as a cause of toxic leukoencephalopathy in a 27-year-old patient: a case report |
| title_fullStr | Marchiafava-Bignami disease as a cause of toxic leukoencephalopathy in a 27-year-old patient: a case report |
| title_full_unstemmed | Marchiafava-Bignami disease as a cause of toxic leukoencephalopathy in a 27-year-old patient: a case report |
| title_short | Marchiafava-Bignami disease as a cause of toxic leukoencephalopathy in a 27-year-old patient: a case report |
| title_sort | marchiafava bignami disease as a cause of toxic leukoencephalopathy in a 27 year old patient a case report |
| topic | Marchiafava-Bignami disease thiamine toxic leukoencephalopathy MRI case report |
| url | https://www.tandfonline.com/doi/10.1080/24734306.2024.2335843 |
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