Epothilone B from Aspergillus fumigatus with a strong antiproliferative and anti-tubulin polymerizing activities; apoptosis, and cell cycle analyses

Epothilone B from Aspergillus fumigatus with a strong antiproliferative and anti-tubulin polymerizing activities; apoptosis, and cell cycle analyses

Abstract Epothilones were designated as one of the most recognized chemotherapeutic agents towards the drug-resistant tumors, for their higher potency to bind and stabilize the β-tubulin arrays, stopping the cell cycle. Epothilones were chemically resolved from Aspergillus fumigatus # MN744705.1, th...

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Bibliographic Details
Main Authors: Ashraf S. A. El-Sayed, Safa W. Aziz, Ahmed H. Moustafa, Noha M. Saad, Mohamed Ali
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Microbiology
Subjects:
Aspergillus fumigatus
Epothilone B
LC–MS/MS analysis
Anticancer activity
Apoptosis
Cell cycle analysis
Online Access:https://doi.org/10.1186/s12866-025-04086-1
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