DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF INTRATHECAL SYNTHESIS OF IMMUNOGLOBULIN FREE LIGHT CHAINS IN MULTIPLE SCLEROSIS

DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF INTRATHECAL SYNTHESIS OF IMMUNOGLOBULIN FREE LIGHT CHAINS IN MULTIPLE SCLEROSIS

Increased intrathecal synthesis and oligoclonal banding of immunoglobulins (Ig) in cerebrospinal fluid (CSF) are major immunological findings in multiple sclerosis. Free light chains are fragments of Ig molecules that are produced in parallel to oligoclonal Ig, and their production reflects total Ig...

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Bibliographic Details
Main Authors: V. D. Nazarov, S. V. Lapin, E. A. Surkova, E. P. Evdoshenko, G. S. Makshakov, Areg A. Totolian
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2015-06-01
Series:Медицинская иммунология
Subjects:
multiple sclerosis
free light chains
clinically isolated syndrome
oligoclonal bands
cerebrospinal fluid
Online Access:https://www.mimmun.ru/mimmun/article/view/888
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