CYP1B1 Knockout in a Bovine Hepatocyte-like Cell Line (BFH12) Unveils Its Role in Liver Homeostasis and Aflatoxin B1-Induced Hepatotoxicity

CYP1B1 Knockout in a Bovine Hepatocyte-like Cell Line (BFH12) Unveils Its Role in Liver Homeostasis and Aflatoxin B1-Induced Hepatotoxicity

CYP1B1 is a key enzyme involved in xenobiotic and endogenous metabolism, yet its physiological role in bovine liver homeostasis remains unclear. In this study, we generated a <i>CYP1B1</i> knockout (<i>CYP1B1</i><sup>KO</sup>) bovine hepatocyte-like cell line to i...

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Bibliographic Details
Main Authors: Silvia Iori, Ludovica Montanucci, Caterina D’Onofrio, Maija Lahtela-Kakkonen, Lorena Lucatello, Anisa Bardhi, Andrea Barbarossa, Francesca Capolongo, Anna Zaghini, Marianna Pauletto, Mauro Dacasto, Mery Giantin
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Toxins
Subjects:
CYP1B1
bovine
liver
AFB1
molecular docking
CRISPR/Cas9
Online Access:https://www.mdpi.com/2072-6651/17/6/294
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