Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis

Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis

Postoperative cognitive dysfunction (POCD) is driven in part by microglial activation and the resulting neuroinflammatory response. Emerging evidence suggests that microRNAs regulate key inflammatory pathways in the central nervous system. In this study, we examined the role of the mmu‑miR‑125a/TRAF...

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Bibliographic Details
Main Authors: Xu Zhiyan, Zhong Kaihua, Chen Weiyuan, Lan Huixia, Zhong Weifeng, Wang XiaoHong, Chen Mu, Pan Bin
Format: Article
Language:English
Published: De Gruyter 2025-07-01
Series:Open Medicine
Subjects:
pocd
dexmedetomidine
mir-125a
traf6
microglial activation
Online Access:https://doi.org/10.1515/med-2025-1236
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https://doi.org/10.1515/med-2025-1236

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