Effect of progesterone sequential therapy on follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) in perimenopausal dysfunctional uterine bleeding
Background: Perimenopausal dysfunctional uterine bleeding (PDUB) is a common gynaecological disease with various clinical treatment options. The objective of this work was to investigate the clinical effect of female progesterone sequential therapy (FPST) on PDUB and follicle-stimulating hormone (FS...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| author | Wu Song Wang Huiru Zhao Yuwei Tang Bo Zhang Qi Li Dapeng |
| author_facet | Wu Song Wang Huiru Zhao Yuwei Tang Bo Zhang Qi Li Dapeng |
| author_sort | Wu Song |
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| description | Background: Perimenopausal dysfunctional uterine bleeding (PDUB) is a common gynaecological disease with various clinical treatment options. The objective of this work was to investigate the clinical effect of female progesterone sequential therapy (FPST) on PDUB and follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2). Methods: 140 cases of PDUB patients were enrolled and randomly rolled into an observation (Obs) group and a control (Ctrl) group, with 70 cases in each. The patients in the Ctrl group were given pure curettage treatment, and those in the Obs group were supplemented with FPST based on the intervention in the Ctrl group. Results: The therapeutic effects of patients in different groups were compared. The cure rate (CR) and total effective rate (TER) in the Obs group were 84.26% and 97.14%, respectively, which were much higher than those in the Ctrl group (44.29% and 74.29%), showing great differences (P< 0.05). The incidence of adverse reactions in the Obs group and Ctrl group were 4.29% (3/70) and 2.86% (2/70), respectively, exhibiting no great difference (P> 0.05). Additionally, after 3 months of follow-up, the recurrence rate was 1.43% (1/70) in the Obs group, which was much higher than 44.29% (31/70) in the Ctrl group, presenting a remarkable difference with P< 0.05. Auda Furqan Moein. |
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| institution | Matheson Library |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
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| series | Journal of Medical Biochemistry |
| spelling | doaj-art-d689dbc9721a40e6a1ceb0cd34d746c72025-07-07T08:50:30ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144365365910.5937/jomb0-532291452-82582503653WEffect of progesterone sequential therapy on follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) in perimenopausal dysfunctional uterine bleedingWu Song0Wang Huiru1Zhao Yuwei2Tang Bo3Zhang Qi4Li Dapeng5Yanshan University, Post Doctoral Station of Control Science and Engineering, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao, Hebei Province, ChinaHebei North University, Graduate School, Zhangjiakou, Hebei Province, ChinaHebei North University, Graduate School, Zhangjiakou, Hebei Province, ChinaHebei North University, Graduate School, Zhangjiakou, Hebei Province, ChinaHebei North University, Graduate School, Zhangjiakou, Hebei Province, ChinaThe Fourth Hospital of Qinhuangdao City, Department of Internal Medicine III, Qinhuangdao, Hebei Province, ChinaBackground: Perimenopausal dysfunctional uterine bleeding (PDUB) is a common gynaecological disease with various clinical treatment options. The objective of this work was to investigate the clinical effect of female progesterone sequential therapy (FPST) on PDUB and follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2). Methods: 140 cases of PDUB patients were enrolled and randomly rolled into an observation (Obs) group and a control (Ctrl) group, with 70 cases in each. The patients in the Ctrl group were given pure curettage treatment, and those in the Obs group were supplemented with FPST based on the intervention in the Ctrl group. Results: The therapeutic effects of patients in different groups were compared. The cure rate (CR) and total effective rate (TER) in the Obs group were 84.26% and 97.14%, respectively, which were much higher than those in the Ctrl group (44.29% and 74.29%), showing great differences (P< 0.05). The incidence of adverse reactions in the Obs group and Ctrl group were 4.29% (3/70) and 2.86% (2/70), respectively, exhibiting no great difference (P> 0.05). Additionally, after 3 months of follow-up, the recurrence rate was 1.43% (1/70) in the Obs group, which was much higher than 44.29% (31/70) in the Ctrl group, presenting a remarkable difference with P< 0.05. Auda Furqan Moein.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582503653W.pdfprogesterone sequential therapyperimenopausal dysfunctional uterine bleedingclinical effectcurettage treatmentfollicle-stimulating hormoneluteinizing hormoneestradiol |
| spellingShingle | Wu Song Wang Huiru Zhao Yuwei Tang Bo Zhang Qi Li Dapeng Effect of progesterone sequential therapy on follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) in perimenopausal dysfunctional uterine bleeding Journal of Medical Biochemistry progesterone sequential therapy perimenopausal dysfunctional uterine bleeding clinical effect curettage treatment follicle-stimulating hormone luteinizing hormone estradiol |
| title | Effect of progesterone sequential therapy on follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) in perimenopausal dysfunctional uterine bleeding |
| title_full | Effect of progesterone sequential therapy on follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) in perimenopausal dysfunctional uterine bleeding |
| title_fullStr | Effect of progesterone sequential therapy on follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) in perimenopausal dysfunctional uterine bleeding |
| title_full_unstemmed | Effect of progesterone sequential therapy on follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) in perimenopausal dysfunctional uterine bleeding |
| title_short | Effect of progesterone sequential therapy on follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) in perimenopausal dysfunctional uterine bleeding |
| title_sort | effect of progesterone sequential therapy on follicle stimulating hormone fsh luteinizing hormone lh and estradiol e2 in perimenopausal dysfunctional uterine bleeding |
| topic | progesterone sequential therapy perimenopausal dysfunctional uterine bleeding clinical effect curettage treatment follicle-stimulating hormone luteinizing hormone estradiol |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582503653W.pdf |
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