CHANGES IN GLUTATHIONE PEROXIDASE ACTIVITY IN CARDIAC TISSUES OF RATS IN RESPONSE TO MECHANICAL INJURY OF THE BLOOD-OCULAR BARRIER
Mechanical eye injury and damage to the blood-ocular barrier cause inflammation resulting in oxidative stress, which, in turn, triggers myocardial ischemia, since the heart's need for oxygen exceeds its supply. A rapid decrease in the oxygen concentration in ischemic tissues causes a switch fr...
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| Format: | Article |
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Private institution educational organization of higher education "Medical University "ReaViz"
2021-02-01
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| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
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| Online Access: | https://vestnik.reaviz.ru/jour/article/view/113 |
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| author | O. N. Gulenko A. A. Devyatkin P. V. Boriskin O. N. Pavlova V. V. Leonov R. G. Karimova |
| author_facet | O. N. Gulenko A. A. Devyatkin P. V. Boriskin O. N. Pavlova V. V. Leonov R. G. Karimova |
| author_sort | O. N. Gulenko |
| collection | DOAJ |
| description | Mechanical eye injury and damage to the blood-ocular barrier cause inflammation resulting in oxidative stress, which, in turn, triggers myocardial ischemia, since the heart's need for oxygen exceeds its supply. A rapid decrease in the oxygen concentration in ischemic tissues causes a switch from oxidative to anaerobic metabolism, when energy deficit initiates a chain of physiological processes. The discovery of the molecular mechanisms underlying the manifestation of oxidative stress in the cardiac tissues will enable the development of effective therapeutic approaches to such condition. Objective: to analyze the dynamics of glutathione peroxidase (GP) activity in cardiac tissues of rats in response to oxidative stress caused by mechanical eye injury.Materials and methods. In our experiment, we used 150 healthy white mature (8-month old) male rats weighing 190–210 g and kept under standard conditions in a vivarium. GP activity was evaluated before the experiment and then on days 1, 3, 5, 7, and 14. Nonparametric statistical analysis was used in this study. Conclusion. GP activity in cardiac tissues of rats during oxidative stress caused by mechanical eye injury was most effectively stabilized by standard treatment for mechanical eye injury plus injections of quercetin. |
| format | Article |
| id | doaj-art-d643c8f342da4d0ab04b616e4e49c8fe |
| institution | Matheson Library |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| publishDate | 2021-02-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj-art-d643c8f342da4d0ab04b616e4e49c8fe2025-08-03T13:33:55ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792021-02-0105364410.20340/vmi-rvz.2020.5.3114CHANGES IN GLUTATHIONE PEROXIDASE ACTIVITY IN CARDIAC TISSUES OF RATS IN RESPONSE TO MECHANICAL INJURY OF THE BLOOD-OCULAR BARRIERO. N. Gulenko0A. A. Devyatkin1P. V. Boriskin2O. N. Pavlova3V. V. Leonov4R. G. Karimova5Federal State Budgetary Institution of Higher Education Samara State University of Railway TransportTestGene’ LLCPrivate Institution of Higher Education ‘Medical University ‘Reaviz’Federal State Budgetary Institution of Higher Education Samara State University of Railway TransportPrivate Institution of Higher Education ‘Medical University ‘Reaviz’Federal State Budgetary Institution of Higher Education N.E. Bauman Kazan State Academy of Veterinary MedicineMechanical eye injury and damage to the blood-ocular barrier cause inflammation resulting in oxidative stress, which, in turn, triggers myocardial ischemia, since the heart's need for oxygen exceeds its supply. A rapid decrease in the oxygen concentration in ischemic tissues causes a switch from oxidative to anaerobic metabolism, when energy deficit initiates a chain of physiological processes. The discovery of the molecular mechanisms underlying the manifestation of oxidative stress in the cardiac tissues will enable the development of effective therapeutic approaches to such condition. Objective: to analyze the dynamics of glutathione peroxidase (GP) activity in cardiac tissues of rats in response to oxidative stress caused by mechanical eye injury.Materials and methods. In our experiment, we used 150 healthy white mature (8-month old) male rats weighing 190–210 g and kept under standard conditions in a vivarium. GP activity was evaluated before the experiment and then on days 1, 3, 5, 7, and 14. Nonparametric statistical analysis was used in this study. Conclusion. GP activity in cardiac tissues of rats during oxidative stress caused by mechanical eye injury was most effectively stabilized by standard treatment for mechanical eye injury plus injections of quercetin.https://vestnik.reaviz.ru/jour/article/view/113oxidative stressheart tissuesblood-ocular barrierratsmechanical eye injuryglutathione peroxidase |
| spellingShingle | O. N. Gulenko A. A. Devyatkin P. V. Boriskin O. N. Pavlova V. V. Leonov R. G. Karimova CHANGES IN GLUTATHIONE PEROXIDASE ACTIVITY IN CARDIAC TISSUES OF RATS IN RESPONSE TO MECHANICAL INJURY OF THE BLOOD-OCULAR BARRIER Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье oxidative stress heart tissues blood-ocular barrier rats mechanical eye injury glutathione peroxidase |
| title | CHANGES IN GLUTATHIONE PEROXIDASE ACTIVITY IN CARDIAC TISSUES OF RATS IN RESPONSE TO MECHANICAL INJURY OF THE BLOOD-OCULAR BARRIER |
| title_full | CHANGES IN GLUTATHIONE PEROXIDASE ACTIVITY IN CARDIAC TISSUES OF RATS IN RESPONSE TO MECHANICAL INJURY OF THE BLOOD-OCULAR BARRIER |
| title_fullStr | CHANGES IN GLUTATHIONE PEROXIDASE ACTIVITY IN CARDIAC TISSUES OF RATS IN RESPONSE TO MECHANICAL INJURY OF THE BLOOD-OCULAR BARRIER |
| title_full_unstemmed | CHANGES IN GLUTATHIONE PEROXIDASE ACTIVITY IN CARDIAC TISSUES OF RATS IN RESPONSE TO MECHANICAL INJURY OF THE BLOOD-OCULAR BARRIER |
| title_short | CHANGES IN GLUTATHIONE PEROXIDASE ACTIVITY IN CARDIAC TISSUES OF RATS IN RESPONSE TO MECHANICAL INJURY OF THE BLOOD-OCULAR BARRIER |
| title_sort | changes in glutathione peroxidase activity in cardiac tissues of rats in response to mechanical injury of the blood ocular barrier |
| topic | oxidative stress heart tissues blood-ocular barrier rats mechanical eye injury glutathione peroxidase |
| url | https://vestnik.reaviz.ru/jour/article/view/113 |
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